文章摘要
符 青,林雪娟,张纯萍,符少娘,黄丽云.脑栓通联合丁苯酞治疗缺血性脑卒中的临床价值分析[J].,2021,(3):553-556
脑栓通联合丁苯酞治疗缺血性脑卒中的临床价值分析
Analysis of Clinical Value of Naoshuantong Combined with Butylphthalide in the Treatment of Ischemic Stroke
投稿时间:2020-04-23  修订日期:2020-05-17
DOI:10.13241/j.cnki.pmb.2021.03.033
中文关键词: 急性缺血性脑卒中  脑栓通  丁苯酞  氧化应激  血流动力学
英文关键词: Acute ischemic stroke  Naoshuantong  Butylphthalide  Oxidative stress  Hemodynamics
基金项目:海南省卫生计生行业科研项目(1341000350A2010)
作者单位
符 青 海南医学院第一附属医院药学部 海南 海口 570102 
林雪娟 海南医学院第一附属医院神经内科 海南 海口 570102 
张纯萍 海南医学院第一附属医院药学部 海南 海口 570102 
符少娘 海南医学院第一附属医院药学部 海南 海口 570102 
黄丽云 海南医学院第一附属医院药学部 海南 海口 570102 
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中文摘要:
      摘要 目的:分析脑栓通联合丁苯酞治疗急性缺血性脑卒中(AIS)的临床价值。方法:选取我院收治的104例AIS患者为研究对象,采用随机数字表法将其分为对照组及观察组,每组各52例。两组均给予抗血小板凝集、控制血压、降糖、调脂等基础治疗,对照组在基础治疗基础上给予丁苯酞治疗,观察组则在对照组基础上予以脑栓通治疗。记录和比较两组的临床疗效、不良反应的发生情况,治疗前及治疗2周后神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)]、血清炎性因子[超敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)]水平、氧化应激指标[脂质过氧化物(LPO)、甘胱甘肽过氧化物酶(GSH-Px)]、血流动力学指标[大脑中动脉(MCA)收缩期血流速度(Vs)、平均血液流速(Vm)]的变化。结果:治疗后,观察组临床总有效率为96.15%,明显高于对照组(P<0.05)。两组治疗期间并发症发生率比较差异无统计学意义(P>0.05)。治疗2周后,两组NIHSS评分、血清hs-CRP、IL-8、LPO水平均较治疗前显著降低(P<0.05),GSH-Px、MCA Vs和Vm则较治疗前明显升高(P<0.05),且观察组以上指标的变化明显优于对照组(P<0.05)。结论:脑栓通联合丁苯酞治疗AIS具有较好的疗效及较高的安全性,可减轻机体炎症反应与氧化应激反应,改善脑血流灌注及神经功能。
英文摘要:
      ABSTRACT Objective: To analyze the clinical value of Naoshuantong combined with butylphthalide in the treatment of acute ischemic stroke (AIS). Methods: 104 AIS patients treated in our hospital were selected as study subjects, and they were divided into the control group and the observation group according to the random number table method, with 52 cases in each group. Both groups were given conventional treatments including anti-platelet aggregation, blood pressure control, blood glucose reduction and lipid regulation, and the control group was additionally given butylphthalide, and observation group was treated with Naoshuantong on the basis of control group. The clinical efficacy, occurrence of adverse reactions, changes of neurologic deficit degree [National Institute of Health Stroke Scale (NIHSS)], inflammatory factors [high-sensitivity C-reactive protein (hs-CRP), interleukin-8 (IL-8), oxidative stress indexes [lipid peroxide (LPO), glutathione peroxidase (GSH-Px)] and hemodynamic indicators [middle cerebral artery (MCA) systolic blood flow velocity (Vs), mean blood flow velocity (Vm)] were compared between the two groups before treatment and after 2 weeks of treatment. Results: After treatment, the total clinical effective rate was 96.15% in the observation group, which was significantly higher than that of the control group (P<0.05). There was no significant difference in the incidence rate of complications between the two groups during treatment (P>0.05). After 2 weeks of treatment, the NIHSS score, serum hs-CRP, IL-8 and LPO in the two groups were lower than those before treatment (P<0.05) while the GSH-Px, MCA Vs, and Vm were higher than those before treatment (P<0.05), and the changes of the above indexes in observation group were significantly better than those in control group (P<0.05). Conclusion: Naoshuantong combined with butylphthalide has better efficacy and higher safety in the treatment of AIS, it can relieve the inflammatory response and oxidative stress, improve the cerebral blood flow perfusion and neurological function.
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