| 彭 东,刘学芬,刘徽婷,何 燕,王荣辉.甲状腺根治术后不同剂量131I清甲治疗对分化型甲状腺癌患者唾液流率、骨代谢和生活质量的影响[J].,2021,(3):537-540 |
| 甲状腺根治术后不同剂量131I清甲治疗对分化型甲状腺癌患者唾液流率、骨代谢和生活质量的影响 |
| Effects of Different Doses of 131I Nail Removal Therapy on Salivary Flow Rate, Bone Metabolism and Quality of Life in Patients with Differentiated Thyroid Cancer after Radical Thyroidectomy |
| 投稿时间：2020-06-16 修订日期：2020-07-12 |
| DOI：10.13241/j.cnki.pmb.2021.03.029 |
| 中文关键词: 甲状腺根治术 不同剂量 131I清甲治疗 分化型甲状腺癌 唾液流率 骨代谢 生活质量 |
| 英文关键词: Radical thyroidectomy Different doses 131I nail removal therapy Differentiated thyroid cancer Salivary flow rate Bone metabolism Quality of life |
| 基金项目:重庆市区域医学重点学科建设项目(zdxk201919) |
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| 摘要 目的：探讨甲状腺根治术后不同剂量131I清甲治疗对分化型甲状腺癌患者唾液流率、骨代谢和生活质量的影响。方法：选取2018年1月~2020年1月期间我院诊治的分化型甲状腺癌患者141例，根据随机数字表法分为低剂量组[治疗剂量为1.1～3.7GBq(30～100 mci)]、中剂量组[治疗剂量为 3.7～5.5GBq(100～150 mci)]、高剂量组[治疗剂量为 5.5～7.4GBq(150 ～ 200 mci)]，各47例。对比三组患者唾液流率、骨代谢、生活质量、腮腺和颌下腺的摄取参数（UR）和排泌参数（ER）。结果：高剂量组、中剂量组腮腺、颌下腺的左侧UR、右侧UR、左侧ER、右侧ER均低于低剂量组，且高剂量组低于中剂量组（P<0.05）。三组治疗后静态唾液流率（UWSFR）、动态唾液流率（SWSFR）均较治疗前下降（P<0.05），高剂量组、中剂量组治疗后UWSFR、SWSFR低于低剂量组，且高剂量组低于中剂量组（P<0.05）。低剂量组、中剂量组的优良率高于高剂量组，且中剂量组高于低剂量组（P<0.05）。三组治疗前后、组间总Ⅰ型胶原氨基端前肽 （PINP）、 β- 胶原降解产物（ β-CTX ）、骨密度（BMD）对比，差异均无统计学意义（P>0.05）。结论：不同剂量131I清甲治疗对分化型甲状腺癌患者的骨代谢无明显影响，但不同剂量131I清甲治疗均会影响患者唾液腺功能及生活质量，其中高剂量 131I清甲对患者的影响最为显著。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of different doses of 131I nail removal therapy on salivary flow rate, bone metabolism and quality of life in patients with differentiated thyroid cancer after radical thyroidectomy. Methods: 141 patients with differentiated thyroid cancer from January 2018 to January 2020 in our hospital were selected, and were randomly divided into low-dose group [therapeutic dose was 1.1~3.7 GBq(30 ~ 100 MCI)], medium dose group [therapeutic dose was 3.7～5.5 GBq(100～150 mci)] and high-dose group [therapeutic dose was 5.5~7.4GBq(150～200mci)], 47 cases in each group. Salivary flow rate, bone metabolism, quality of life, uptake fraction (UR) and excretion fraction (ER) of parotid and submandibular glands were compared among the three groups. Results: The left UR, right UR, left ER and right ER of parotid gland and submandibular gland in high-dose group and middle dose group were lower than those in low-dose group, and those in high-dose group were lower than those in medium dose group (P<0.05). After treatment, the static salivary flow rate (UWSFR) and dynamic salivary flow rate (SWSFR) of the two groups decreased compared with those before treatment (P<0.05). After treatment, the UWSFR and SWSFR of the high-dose group and the medium dose group were lower than those of the low-dose group, and the high-dose group was lower than the medium dose group (P<0.05). The excellent and good rate of low-dose group and medium dose group were higher than that of high-dose group, and that of medium dose group was higher than that of low-dose group (P<0.05). Between three groups before and after treatment, the total collagen type Ⅰ amino terminal propeptide (PINP), β-collagen degradation products (β-CTX), bone mineral density (BMD) in contrast, there were no statistically significant differences (P>0.05). Conclusion: Different doses of 131I nail removal therapy has no significant effect on bone metabolism in patients with differentiated thyroid cancer, but different doses of 131I nail removal therapy all have an effect on salivary gland function and quality of life in patients, among which high-dose of 131I nail removal therapy has the most significant effect. |
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