| 王晓芳,徐新宇,许 里,钱 冰,高 玲.胃癌组织miR-203、miR-4317的表达及临床意义[J].,2021,(3):480-484 |
| 胃癌组织miR-203、miR-4317的表达及临床意义 |
| Expression and Clinical Significance of miR-203 and miR-4317 in Gastric Cancer |
| 投稿时间：2020-04-19 修订日期：2020-05-16 |
| DOI：10.13241/j.cnki.pmb.2021.03.016 |
| 中文关键词: 胃癌 miR-203 miR-4317 生存率 预后 危险因素 |
| 英文关键词: Gastric cancer miR-203 miR-4317 Survival rate Prognosis Risk factors |
| 基金项目:江苏省卫生和计划生育委员会科研项目（Z2017624） |
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| 中文摘要: |
| 摘要 目的：探讨胃癌组织中微小核糖核酸（miR）-203、miR-4317的表达情况及其临床意义。方法：选择2014年1月至2016年12月我院收治的胃癌患者92例，应用实时定量荧光PCR（qRT-PCR）检测患者胃癌组织及其相应癌旁组织中miR-203、miR-4317的表达情况，分析miR-203、miR-4317表达与胃癌患者临床病理参数的关系，所有患者随访3年，根据miR-203、miR-4317在胃癌组织中的中位表达量将患者分为miR-203高表达组(49例)、miR-203低表达组(43例)、miR-4317高表达组(51例)、miR-4317低表达组(41例)。分析miR-203、miR-4317与预后的关系及预后的影响因素。结果：胃癌组织中miR-203、miR-4317相对表达量显著低于癌旁组织（P＜0.05）。不同性别、年龄、肿瘤大小胃癌患者胃癌组织中miR-203、miR-4317相对表达量比较无统计学差异（P>0.05），中低分化、TNM分期为III~IV期、有淋巴结转移胃癌患者胃癌组织中miR-203、miR-4317相对表达量显著低于高分化、TNM分期为I~II期、无淋巴结转移胃癌患者（P＜0.05）。miR-203高表达组3年生存率显著高于miR-203低表达组（P＜0.05），miR-4317高表达组3年生存率显著高于miR-4317低表达组（P＜0.05）。COX多因素分析显示，中低分化、TNM分期为III~IV期、有淋巴结转移、miR-203低表达、miR-4317低表达是影响胃癌患者预后的独立危险因素（P＜0.05）。结论：胃癌组织中miR-203、miR-4317异常低表达，其水平与胃癌预后密切相关，且胃癌患者预后与分化程度、临床分期、淋巴结转移等相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of MicroRNA (miR)-203 and miR-4317 in gastric cancer. Methods: 92 cases of gastric cancer in our hospital from January 2014 to December 2016 were selected. The expression of miR-203 and miR-4317 in gastric cancer and its adjacent tissues were detected by real-time quantitative PCR (qRT-PCR). The relationship between the expression of miR-203 and miR-4317 and the clinicopathological parameters of gastric cancer was analyzed. All patients were followed up for 3 years. According to the median expression of miR-203 and miR-4317 in gastric cancer, the patients were divided into miR-203 high expression group (49 cases), miR-203 low expression group (43 cases), miR-4317 high expression group (51 cases), miR-4317 low expression group (41 cases). The relationship between miR-203, miR-4317 and prognosis and the influencing factors of prognosis were analyzed. Results: The expression of miR-203 and miR-4317 in gastric cancer were significantly lower than those in adjacent tissues (P<0.05). There were no significant differences in the relative expression of miR-203 and miR-4317 in gastric cancer tissues of different gender, age and tumor size (P>0.05). The relative expression of miR-203 and miR-4317 in gastric cancer tissues of moderately low differentiation, TNM stage III-IV, and with lymph node metastasis were significantly lower than those of high differentiation, TNM stage I-II, and no lymph node metastasis(P<0.05). The 3-year survival rate of miR-203 high expression group was significantly higher than that of miR-203 low expression group (P＜0.05). The 3-year survival rate of miR-4317 high expression group was significantly higher than that of miR-4317 low expression group (P＜0.05). Cox multivariate analysis showed that moderately low differentiation, TNM stage III-IV, with lymph node metastasis, miR-203 low expression and miR-4317 low expression were independent risk factors (P<0.05). Conclusion: The expression of miR-203 and mir-4317 are abnormally low in gastric cancer, and the levels of miR-203 and mir-4317 are closely related to the prognosis of gastric cancer. And the prognosis of gastric cancer patients are related to the degree of differentiation, clinical stage and lymph node metastasis. |
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