| 蒋丽华,陈欢雪,白 怡,吴 妍,赵丽萍.狼疮性肾炎患者血清TBX21、SCF、Chemerin水平与病情严重程度的相关性分析[J].,2021,(2):351-355 |
| 狼疮性肾炎患者血清TBX21、SCF、Chemerin水平与病情严重程度的相关性分析 |
| Correlation Analysis of Serum Levels of TBX21, SCF, Chemerin and Severity of Lupus Nephritis |
| 投稿时间：2020-06-18 修订日期：2020-07-13 |
| DOI：10.13241/j.cnki.pmb.2021.02.033 |
| 中文关键词: 狼疮性肾炎 T-框蛋白21 干细胞因子 趋化素 病情 |
| 英文关键词: Lupus nephritis T-Box protein 21 Stem cell factor Chemotaxis element |
| 基金项目:国家自然科学基金面上项目（31571184）；辽宁省自然科学基金项目（2013022055） |
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| 中文摘要: |
| 摘要 目的：研究狼疮性肾炎（LN）患者血清T-框蛋白21（TBX21）、干细胞因子（SCF）、趋化素（Chemerin）水平与病情严重程度的相关性。方法：将2016年2月～2019年12月我院收治的160例LN患者纳入研究，将其按照疾病活动度的不同分成活动期组92例，非活动期组68例。另取同期于我院接受体检的健康志愿者50例作为对照组。比较三组血清尿素氮（BUN）、红细胞沉降率（ESR）、补体C3、C4、TBX21、SCF及Chemerin水平，并作相关性分析。以受试者工作特征（ROC）曲线分析血清TBX21、SCF及Chemerin水平在LN中的诊断能效。结果：活动期组BUN、ESR水平均高于非活动期组，且非活动期组BUN、ESR水平均高于对照组（P＜0.05）；活动期组补体C3、C4水平均低于非活动期组，且非活动期组补体C3、C4水平均低于对照组（P＜0.05）。活动期组血清TBX21、SCF及Chemerin水平均高于非活动期组，且非活动期组血清TBX21、SCF及Chemerin水平均高于对照组（P＜0.05）。经Pearson相关性分析可得：LN患者血清TBX21、SCF及Chemerin水平与BUN、ESR水平均呈正相关，与补体C3、C4水平均呈负相关（P＜0.05）。经ROC曲线分析可得：血清TBX21、SCF及Chemerin水平联合检测诊断狼疮性肾炎的曲线下面积为0.933、灵敏度为0.95、特异度为0.91均高于上述指标单独检测。结论：LN患者血清TBX21、SCF及Chemerin水平均存在明显高表达，且和患者的病情严重程度相关，临床工作中可能通过联合检测上述三项血清学指标，继而达到辅助诊断LN以及判断患者病情严重程度的目的。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between serum levels of T-Box protein 21 (TBX21), stem cell factor (SCF), chemokine (Chemerin) and disease severity in patients with lupus nephritis (LN). Methods: 160 patients with LN who were admitted to our hospital from February 2016 to December 2019 were included in the study, and they were divided into active group with 92 cases and inactive group with 68 cases according to the degree of disease activity. In addition, 50 healthy volunteers who underwent physical examination in our hospital at the same time were selected as the control group. The levels of urea nitrogen(Bun), erythrocyte sedimentation rate(ESR), alexin C3, alexin C4, TBX21, SCF and Chemerin in three groups were compared and the correlation analysis was maked. The diagnostic efficiency of serum TBX21, SCF and Chemerin levels in LN was analyzed by receiver operating characteristic (ROC) curve. Results: The levels of BUN, ESR in the active group were higher than those in the inactive group and the levels of BUN and ESR in the inactive group were higher than those in the control group (P<0.05). The levels of alexin C3 and C4 in the active group were lower than those in the inactive group, and the levels of alexin C3 and C4 in the inactive group were lower than those in the control group (P<0.05). Serum levels of TBX21, SCF and Chemerin in the active group were higher than those in the inactive group, and serum levels of TBX21, SCF and Chemerin in the inactive group were higher than those in the control group (P<0.05). According to Pearson correlation analysis, serum levels of TBX21, SCF and Chemerin in LN patients were positively correlated with BUN and ESR levels, and negatively correlated with alexin C3 and C4 levels (P<0.05). According to ROC curve analysis, the joint detection of serum TBX21, SCF and Chemerin in the diagnosis of lupus nephritis was 0.933 under the curve, 0.95 in sensitivity and 0.91 in specificity, which were higher than the above indexes alone detection. Conclusion: Serum levels of TBX21, SCF and Chemerin in patients with LN are significantly high and they are correlated with the severity of the patient's condition. In clinical work, the three serological indexes mentioned above could be detected in combination to help diagnose LN and determine the severity of the patient's condition. |
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