| 董君宇,王 勃,贾玉涛,张雪玲,姜志红.缬沙坦胶囊联合醋酸泼尼松片治疗原发性肾病综合征患儿的疗效及对肾功能及炎性因子的影响[J].,2021,(2):307-310 |
| 缬沙坦胶囊联合醋酸泼尼松片治疗原发性肾病综合征患儿的疗效及对肾功能及炎性因子的影响 |
| The Effect of Valsartan Capsule Combined with Prednisone Acetate on Children with Primary Nephrotic Syndrome and Its Influence on Renal Function and Inflammatory Factors |
| 投稿时间：2020-03-30 修订日期：2020-04-24 |
| DOI：10.13241/j.cnki.pmb.2021.02.023 |
| 中文关键词: 缬沙坦胶囊 醋酸泼尼松片 原发性肾病综合征 疗效 肾功能 炎性因子 |
| 英文关键词: Valsartan capsule Prednisone Acetate Tablets Primary nephrotic syndrome Efficacy Renal function Inflammatory factors |
| 基金项目:河南省科技攻关项目（62300410675） |
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| 中文摘要: |
| 摘要 目的：探讨原发性肾病综合征（NS）患儿在醋酸泼尼松片治疗的基础上联合缬沙坦胶囊治疗的临床疗效及对肾功能和炎性因子的影响。方法：选取2017年2月~2019年4月期间我院收治的NS患儿107例，根据随机数字表法分为对照组（n=53，醋酸泼尼松片治疗）和研究组（n=54，对照组的基础上联合缬沙坦胶囊治疗），比较两组患儿的临床疗效、肾功能指标及炎性因子指标变化情况，记录两组治疗期间不良反应情况。结果：研究组治疗12周后的临床总有效率为90.74%（49/54），高于对照组的69.81%（37/53）（P<0.05）。两组患儿治疗12周后白蛋白（Alb）较治疗前升高，24 h尿蛋白定量、肌酐（Cr）、尿素氮（BUN）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白介素-8（IL-8）均较治疗前降低（P<0.05）；研究组治疗12周后Alb高于对照组，24 h尿蛋白定量、Cr、BUN、IL-6、IL-8、TNF-α则低于对照组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：缬沙坦胶囊联合醋酸泼尼松片治疗在提高NS患儿疗效的同时还可有效改善患儿肾功能及炎性因子水平，用药安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect and its influence on renal function and inflammatory factors of combination of valsartan capsule and prednisone acetate on children with primary nephrotic syndrome (NS). Methods: 107 children with NS who were admitted to our hospital from February 2017 to April 2019 were selected, they were randomly divided into control group (n=53, treatment of prednisone acetate tablets) and study group (n=54, combination of valsartan capsule and control group) according to the random number table. The therapeutic effect, renal function index and inflammatory factor index of the two groups were compared. The adverse reactions of the two groups were recorded. Results: The total effective rate of the study group at 12 weeks after treatment was 90.74% (49/54), which was higher than 69.81% (37/53) of the control group (P<0.05). 12 weeks after treatment, albumin (Alb) of the two groups were higher than that before treatment, while 24-hour urine protein, Creatinine (Cr), urea nitrogen (BUN), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) were lower than those before treatment (P<0.05). Alb of the study group at 12 weeks after treatment was higher than that of the control group, the 24 h urine protein quantification, Cr, BUN, IL-6, IL-8, TNF-α were lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Valsartan capsule combined with prednisone acetate tablets is effective in the treatment of children with NS, but also it can effectively improve the renal function and the level of inflammatory factors, and the drug safety is safety. |
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