| 李 响,马芙蓉,李嘉伦,李健成,刘锦宇.褪黑素和褪黑素受体对下丘脑-垂体-肾上腺轴作用的研究进展[J].,2021,(1):197-200 |
| 褪黑素和褪黑素受体对下丘脑-垂体-肾上腺轴作用的研究进展 |
| Research Progress of Melatonin and Melatonin Receptor Function on Hypothalamic-pituitary-adrenal Axis |
| 投稿时间：2020-07-26 修订日期：2020-08-22 |
| DOI：10.13241/j.cnki.pmb.2021.01.044 |
| 中文关键词: 褪黑素 褪黑素受体 下丘脑-垂体-肾上腺轴 免疫功能 松果体 |
| 英文关键词: Melatonin Melatonin receptor Hypothalamic-pituitary-adrenal axis Immune function Pineal gland |
| 基金项目:甘肃省自然科学基金项目（1506KJZA239） |
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| 中文摘要: |
| 摘要：松果体于儿童中期可发育至最高峰，普遍在7岁之后开始呈逐渐萎缩，并在成年后逐渐有钙盐沉着。褪黑素主要是由松果体进行合成和分泌所形成，存在较好的昼夜节律性，且通常是通过下丘脑的视交叉上核进行控制，并与环境中的光-暗呈现的周期改变存在密切关联。此外，褪黑素具有极其广泛的生物学作用，且其发挥作用的首站便是与特异性褪黑素受体相关结合，随后经由信号转导系统发挥相应的生物效应。褪黑素受体属于G蛋白耦联受体超家族重要成员之一，其主要是通过百日咳毒素敏感G蛋白的一致性G蛋白通路，减少环腺苷酸的急剧或（和）抑制毛喉菇素刺激的环腺苷酸升高，从而间接影响黑色素活动。下丘脑-垂体-肾上腺轴（HPA轴）是机体在发生应激反应过程中具有一定影响的系统，其所分泌的激素也会表现出昼夜节律性的改变，且此种改变与褪黑素的有关变化呈现出明显的相反性。提示了两者可能存在一定的相关，在机体免疫功能的调控中扮演着不同的角色。本文通过阐述褪黑素和褪黑素受体对HPA轴作用的最新研究进展，旨在明确三者存在的错综复杂的相互作用关系，继而为机体免疫功能调控的一系列疾病研究提供参考依据。 |
| 英文摘要: |
| ABSTRACT: The pineal gland can reach its peak in the middle of childhood. Generally, it began to shrink after 7 years old and there is gradually calcium deposition in adulthood. Melatonin is mainly formed by the synthesis and secretion of pineal gland, it has a good circadian rhythm and it is usually controlled by the suprachiasmatic nucleus of the hypothalamus, it is closely related to the periodic change of light-dark presentation in the environment. In addition, melatonin has a wide range of biological functions and the first step for it to work is to bind to specific melatonin receptor, then exert corresponding biological effects through signal transduction system. Melatonin receptor is one of the important members of G protein coupled receptor superfamily, it is mainly through the consistent G protein pathway of pertussis toxin sensitive G protein to decrease the sharp increase of camp or(and) inhibit the increase of camp stimulated by lentinan, then affect melanin activity indirectly. Hypothalamic-pituitary-adrenal axis(HPA axis) is a system that the body has certain influence in the process of stress reaction, the hormones it secretes also show circadian rhythm changes, this kind of change and the melatonin related change present the obvious opposite. It suggests that there may be some correlation between them, they play different roles in the regulation of immune function. In this paper, the latest research progress of melatonin and melatonin receptor function on the HPA axis was reviewed. Its aim at clarify the complicated interaction among the three, then provides reference for the study of a series of diseases regulated by immune function. |
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