| 肖 燕,夏 琛,金冬梅,马 雯,阎 蓓.高危型人乳头瘤病毒、P16和ki67在宫颈上皮内瘤变临床意义及相互关系[J].,2021,(1):70-73 |
| 高危型人乳头瘤病毒、P16和ki67在宫颈上皮内瘤变临床意义及相互关系 |
| Clinical Significance and Correlation of High-risk Human Papillomavirus, P16 and ki67 in Cervical Intraepithelial Neoplasia |
| 投稿时间：2020-03-29 修订日期：2020-04-25 |
| DOI：10.13241/j.cnki.pmb.2021.01.014 |
| 中文关键词: 高危型人乳头瘤病毒 P16 ki67 宫颈上皮内瘤变 临床意义 相互关系 |
| 英文关键词: High-risk human papillomavirus P16 ki67 Cervical intraepithelial neoplasia Clinical significance Correlation |
| 基金项目:湖北省自然科学基金项目（WJ2017F020） |
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| 中文摘要: |
| 摘要 目的：探究P16、ki67和高危型人乳头瘤病毒（human papillomavirus，HPV）在宫颈上皮内瘤变中诊断临床意义，并就上述指标的相关性进行分析。方法：选择2019年1月至2019年12月于我院接受治疗的31例宫颈炎患者、45例上皮内瘤变患者（其中25例为低级别上皮内瘤变，20例为高级别上皮内瘤变）为研究对象，分别对上述患者采用免疫组化法检测P16和ki67的表达，并采用PCR法对高危型人乳头瘤病毒的表达进行检测，而后实施组间比对。结果：高级别人乳头瘤变组和低级别人乳头瘤变高于宫颈炎组（P<0.05），高级别人乳头瘤病变组感染率高于低级别人乳头瘤变组，但是对比无统计学意义（P>0.05）；P16表达阳性率由高至低为高级别内瘤变组、低级别内瘤变组和宫颈炎组，各组间表达阳性率比对差异具有统计学意义（P<0.05）；ki67表达阳性率由高至低为高级别内瘤变组、低级别内瘤变组和宫颈炎组，各组间表达阳性率比对差异具有统计学意义（P<0.05）；P16和ki67表达阳性率与HPV16/18感染率呈正相关联系（P<0.05）。结论：高危型人乳头瘤病毒、P16以及ki67对宫颈上皮内瘤变具有较好的诊断鉴别价值，可依据上述指标判断患者病程进展程度，对临床治疗具有一定指导意义。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical significance of P16, ki67 and high-risk human papillomavirus (HPV) in the diagnosis of cervical intraepithelial neoplasia, and to analyze the correlation of the above indicators. Methods: From January 2019 to December 2019, 31 patients with cervicitis and 45 patients with intraepithelial neoplasia (25 cases of low-grade intraepithelial neoplasia and 20 cases of high-grade intraepithelial neoplasia) were treated in our hospital as the research object, the expression of P16 and ki67 was detected by immunohistochemistry in the above patients, and the high-risk human papilloma virus expression was detected by PCR method, and then the group comparison. Results: The papillomas in the advanced others and the papillomas in the lower grades were higher than those in the cervicitis group (P<0.05). The infection rate of the papilloma lesions in the high-grade others was higher than that in the low-grade papillomas, but there was no significant difference (P>0.05). The positive rate of P16 expression was changed from high to low to high-grade internal tumorigenic group, low-grade internal tumorigenic group and cervicitis group. The positive expression rate comparison between the groups was statistically significant (P<0.05). ki67 expression positive rate From high to low, there was a high-level intratumoral change group, a low-level intratumoral change group, and a cervicitis group. There was a statistically significant difference in the positive rate comparison between the groups (P<0.05). The positive rate of P16 and ki67 expression was positively correlated with the infection rate of HPV16/18 (P<0.05). Conclusion: High-risk human papillomavirus, P16 and ki67 have a good diagnostic value for cervical intraepithelial neoplasia. The above indicators can be used to judge the progress of the patient's disease course and have certain guiding significance for clinical treatment. |
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