| 范晓利,康 璇,吴 侃,李书芳,周 宇.大动脉粥样硬化性脑梗死合并SCH患者甲状腺激素与血脂、BDNF及Hcy的关系研究[J].,2020,(24):4768-4771 |
| 大动脉粥样硬化性脑梗死合并SCH患者甲状腺激素与血脂、BDNF及Hcy的关系研究 |
| Study on the Relationship between Thyroid Hormone, Blood Lipid, BDNF and Hcy in Patients with Atherosclerotic Cerebral Infarction and SCH |
| 投稿时间：2020-06-23 修订日期：2020-07-17 |
| DOI：10.13241/j.cnki.pmb.2020.24.038 |
| 中文关键词: 大动脉粥样硬化 脑梗死 亚临床甲状腺功能减退 血脂 脑源性神经营养因子 同型半胱氨酸 |
| 英文关键词: Atherosclerosis Cerebral infarction Subclinical hypothyroidism Blood lipid Brain-derived neurotrophic factor Serum homocysteine |
| 基金项目:国家自然科学基金项目（81800687） |
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| 中文摘要: |
| 摘要 目的：探讨大动脉粥样硬化性脑梗死合并亚临床甲状腺功能减退(SCH)患者甲状腺激素与血脂、脑源性神经营养因子(BDNF)以及血清同型半胱氨酸(Hcy)的关系。方法：选取2017年8月~2019年8月期间本院收治的单纯大动脉粥样硬化性脑梗死患者278例纳入脑梗死组，大动脉粥样硬化性脑梗死合并SCH患者122例纳入合并组，另选同期在我院进行体检的健康受试者40例为对照组。检测并对比三组受试者的甲状腺激素、血脂指标、BDNF、Hcy水平，并对大动脉粥样硬化性脑梗死合并SCH患者甲状腺激素与血脂、BDNF、Hcy的相关性进行分析。结果：脑梗死组、合并组患者的促甲状腺激素(TSH)水平均高于对照组，且合并组高于脑梗死组(P<0.05)。脑梗死组、合并组患者的甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)水平均高于对照组，且合并组高于脑梗死组(P<0.05)。脑梗死组、合并组BDNF水平低于对照组，Hcy水平高于对照组，且合并组BDNF水平低于脑梗死组，Hcy水平高于脑梗死组 (P<0.05)。经Pearson相关性分析，大动脉粥样硬化性脑梗死合并SCH患者的TSH水平与TG、TC、LDL-C、Hcy呈正相关性，与BDNF呈负相关性(P<0.05)。结论：脑梗死合并SCH患者甲状腺激素水平与患者的血脂水平、BDNF、Hcy有一定的相关性，初步推测SCH通过影响机体的脂质代谢、升高Hcy水平、降低BDNF水平等途径，加重患者的脑梗死程度。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between thyroid hormone, blood lipid, brain-derived neurotrophic factor (BDNF) and serum homocysteine (Hcy) in patients with atherosclerotic cerebral infarction and subclinical hypothyroidism (SCH). Methods: 278 patients with simple large atherosclerotic cerebral infarction and 122 patients with large atherosclerotic cerebral infarction and sch from August 2017 to August 2019 were included in the cerebral infarction group, and 40 healthy subjects who had physical examination in our hospital at the same time were selected as the control group. The levels of thyroid hormone, blood lipid index, BDNF and Hcy in the three groups were measured and compared. The correlation between thyroid hormone and blood lipid, BDNF and Hcy in patients with large atherosclerotic cerebral infarction complicated with Sch was analyzed. Results: The levels of Thyroid hormone (TSH) in the cerebral infarction group and the combined group were higher than those in the control group, and those in the combined group were higher than those in the cerebral infarction group (P<0.05). The levels of TG, TC and LDL-C in cerebral infarction group and combined group were higher than those in control group, and those in combined group were higher than those in cerebral infarction group (P<0.05). The level of BDNF and Hcy in the cerebral infarction group and the combined group were lower than those in the control group, and the level of BDNF and Hcy in the combined group were higher than those in the cerebral infarction group (P<0.05). By Pearson correlation analysis, TSH level was positively correlated with TG, TC, LDL-C and Hcy, and negatively correlated with BDNF (P<0.05). Conclusion: The level of thyroid hormone in patients with cerebral infarction and SCH is related to the level of blood lipids, BDNF, Hcy, etc. it is preliminarily speculated that SCH patients can aggravate the degree of cerebral infarction by affecting the lipid metabolism, increasing the level of Hcy, reducing the level of BDNF, etc. |
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