| 胡洁玉,封甜舒,王靖明,郑 睿,赵 岩,徐学海.鼻内镜下腺样体切除术联合鼓膜置管术对分泌性中耳炎患儿血清炎症因子和T细胞亚群的影响[J].,2020,(24):4722-4725 |
| 鼻内镜下腺样体切除术联合鼓膜置管术对分泌性中耳炎患儿血清炎症因子和T细胞亚群的影响 |
| The Effect of Adenoidectomy Combined with Tympanic Intubation under Nasal Endoscopy on Serum Inflammatory Factors and T Cell Subsets in Children with Secretory Otitis Media |
| 投稿时间：2020-04-23 修订日期：2020-05-17 |
| DOI：10.13241/j.cnki.pmb.2020.24.027 |
| 中文关键词: 鼻内镜 腺样体切除术 鼓膜置管术 分泌性中耳炎 炎症因子 T细胞亚群 |
| 英文关键词: Nasal endoscope Adenoidectomy Tympanic intubation Secretory otitis media Inflammatory factors T cell subsets |
| 基金项目:甘肃省科技计划资助项目（16YF1WA1045） |
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| 摘要 目的：探讨鼻内镜下腺样体切除术联合鼓膜置管术对分泌性中耳炎（SOM）患儿血清炎症因子和T细胞亚群的影响。方法：选取2016年8月~2018年12月期间我院收治的SOM患儿113例，上述患儿根据随机数字表法分为对照组（n=56）和研究组（n=57），对照组患儿予以鼓膜置管术治疗，研究组则在对照组的基础上联合鼻内镜下腺样体切除术治疗，比较两组患儿疗效、血清炎症因子、T细胞亚群、中耳积液时间、语频区气导平均听阀及并发症。结果：研究组术后3个月的临床总有效率为94.74%（54/57），高于对照组的75.00%（42/56）（P<0.05）。两组术后3个月血清白介素-2（IL-2）、白介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）水平均下降，且研究组低于对照组（P<0.05）。两组术后3个月CD8+下降，且研究组低于对照组（P<0.05）；CD4+、CD4+/ CD8+升高，且研究组高于对照组（P<0.05）。研究组中耳积液时间短于对照组，语频区气导平均听阀高于对照组（P<0.05）。两组术后并发症发生率比较无差异（P>0.05）。结论：鼻内镜下腺样体切除术联合鼓膜置管术治疗SOM患儿，疗效显著，可有效改善血清炎症因子、T细胞亚群、中耳积液时间及语频区气导平均听阀，且安全性较好，临床应用价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of adenoidectomy combined with tympanic intubation under nasal endoscopy on serum inflammatory factors and T cell subsets in children with secretory otitis media (SOM). Methods: From August 2016 to December 2018, 113 children with SOM in our hospital were selected. According to the random number table, the children were divided into the control group(n=56) and study group(n=57). The children in the control group were treated with tympanum catheterization, while the study group was treated with adenoidectomy under nasal endoscope on the basis of the control group. The efficacy, serum inflammatory factors and T cell subsets, time of middle ear effusion, average auditory valve in speech frequency area and complications of the two groups were compared. Results: The total clinical effective rate of the study group was 94.74%(54/57), which was higher than 75.00% (42/56) of the control group(P<0.05). The levels of serum interleukin-2(IL-2), interleukin-6(IL-6) and tumor necrosis factor-α (TNF-α) of the two groups decreased at 3 months after operation, and the levels of the study group were lower than those of the control group (P<0.05). 3 months after operation, CD8+ decreased of the two groups, and it in the study group was lower than that in the control group (P<0.05). CD4+, CD4+/CD8+ increased, and those in the study group were higher than those in the control group(P<0.05). The time of middle ear effusion in the study group was shorter than that in the control group, and the average auditory valve in the speech frequency area was higher than that in the control group(P<0.05). There was no significant difference between the two groups in postoperative complications(P>0.05). Conclusion: Adenoidectomy combined with tympanic intubation under nasal endoscopy is effective in the treatment of SOM children. It can effectively improve the serum inflammatory factors, T cell subsets, the time of middle ear effusion and the average auditory valve in the speech frequency area. It has good safety and high clinical application value. |
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