| 马婷婷,马博雅,陈建红,王 旭,刘爱翠.针灸联合奥拉西坦治疗脑出血的疗效及对患者神经功能和炎性因子的影响[J].,2020,(24):4683-4686 |
| 针灸联合奥拉西坦治疗脑出血的疗效及对患者神经功能和炎性因子的影响 |
| The Effect of Acupuncture Combined with Oxiracetam on Cerebral Hemorrhage and Its Influence on Nerve Function and Inflammatory Factors |
| 投稿时间：2020-03-29 修订日期：2020-04-24 |
| DOI：10.13241/j.cnki.pmb.2020.24.018 |
| 中文关键词: 针灸 奥拉西坦 脑出血 疗效 神经功能 炎性因子 |
| 英文关键词: Acupuncture Oxiracetam Cerebral hemorrhage Efficacy Neurological function Inflammatory factors |
| 基金项目:宁夏回族自治区卫计委科研计划项目（2016NW407） |
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| 中文摘要: |
| 摘要 目的：探讨脑出血患者经针灸联合奥拉西坦治疗后的临床疗效。方法：选取2015年2月2018年7月期间我院收治的90例脑出血患者，根据随机数字表法将患者分为对照组（n=45）和研究组（n=45），对照组给予奥拉西坦治疗，研究组在对照组的基础上联合针灸治疗，比较两组临床疗效、血肿体积、脑水肿体积、神经功能及炎性因子水平，记录两组治疗期间不良反应情况。结果：研究组治疗2个疗程后的临床总有效率为91.11%（41/45），高于对照组的71.11%（32/45）（P<0.05）。治疗2个疗程后，两组患者的简易精神状态量表（MMSE）评分升高，且研究组高于对照组（P<0.05）；两组患者美国国立卫生院卒中量表（NIHSS）评分降低，且研究组低于对照组（P<0.05）；两组白介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）均下降，且研究组低于对照组（P<0.05）。两组不良反应发生率对比无差异（P>0.05）。与治疗第1 d相比，两组治疗第7 d、治疗第28 d血肿体积呈先增大后缩小趋势（P<0.05），脑水肿体积呈持续缩小趋势（P<0.05）；研究组治疗第28 d血肿体积、脑水肿体积小于对照组（P<0.05）。结论：针灸联合奥拉西坦治疗可有效改善脑出血患者的临床症状，减轻炎症反应及神经功能损害，安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of acupuncture combined with Oxiracetam on cerebral hemorrhage and its influence on nerve function and inflammatory factors. Methods: 90 patients with cerebral hemorrhage who were admitted to our hospital in February 2015 and July 2018 were selected, they were divided into control group (n=45) and study group (n=45) according to random number table method. Patients in the control group were treated with oxiracetam, while those in the study group were treated with acupuncture on the basis of the control group. The clinical effect, hematoma volume, brain edema volume, nerve function, cognitive function and inflammatory factors were compared between the two groups, Adverse reactions during treatment were recorded in the two groups. Results: The clinical effect of the study group at 2 courses after treatment was 91.11% (41/45), which was higher than that of the control group 71.11% (32/45) (P<0.05). 2 courses after treatment, mini-mental state examination (MMSE) score of the two groups increased, and that of the study group was higher than that of the control group (P<0.05). The national institutes of health stroke scale (NIHSS) score decreased, and that of the study group was lower than that of the control group (P<0.05). The interleukin-8 (IL-8), tumor necrosis factor -α (TNF-α), and hypersensitive C-reactive protein (hs-CRP) were all decreased in the two groups, and those of the study group were lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Compared with the first day of treatment, the hematoma volume of the two groups increased first and then decreased on the 7th and 28th day of treatment (P<0.05), the volume of brain edema of the two groups decreased continuously (P<0.05). The volume of hematoma and brain edema of the study group were smaller than those of the control group at 28th day after treatment (P<0.05). Conclusion: Acupuncture combined with oxiracetam can effectively improve the clinical symptoms of cerebral hemorrhage patients, reduce the damage of neurological function and inflammation, and it has a good safety. |
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