| 武 岳,刘华一,祁禹德,叶蓝月,徐一舟.酪酸梭菌活菌胶囊联合四联疗法对幽门螺杆菌阳性胃溃疡患者血清炎症因子、胃肠激素和胃蛋酶原亚群的影响[J].,2020,(24):4631-4634 |
| 酪酸梭菌活菌胶囊联合四联疗法对幽门螺杆菌阳性胃溃疡患者血清炎症因子、胃肠激素和胃蛋酶原亚群的影响 |
| Effect of Clostridium Butyricum Capsule Combined with Quadruple Therapy on Serum Inflammatory Factors, Gastrointestinal Hormones and Progastrin Subsets in Patients with Helicobacter Pylori Positive Gastric Ulcer |
| 投稿时间：2020-06-23 修订日期：2020-07-17 |
| DOI：10.13241/j.cnki.pmb.2020.24.007 |
| 中文关键词: 酪酸梭菌活菌胶囊 四联疗法 幽门螺杆菌阳性 胃溃疡 炎症因子 胃肠激素 胃蛋酶原亚群 |
| 英文关键词: Clostridium butyricum capsule Quadruple therapy Helicobacter pylori positive Gastric ulcer Inflammatory factors Gastrointestinal hormones Progastrin subgroup |
| 基金项目:天津市卫计委卫生行业重点攻关项目（15KG149） |
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| 摘要 目的：探讨酪酸梭菌活菌胶囊联合四联疗法对幽门螺杆菌（Hp）阳性胃溃疡患者血清炎症因子、胃肠激素和胃蛋酶原亚群的影响。方法：选择天津市中医药研究院附属医院于2017年2月~2020年3月期间收治的Hp阳性胃溃疡患者100例，按信封抽签法随机分为对照组（50例，采用四联疗法治疗）、观察组（50例，采用酪酸梭菌活菌胶囊联合四联疗法治疗）。对比两组患者疗效、血清炎症因子、胃肠激素、胃蛋酶原亚群、Hp根除率及不良反应。结果：治疗4周后，观察组患者的总有效率为92.00%（46/50），高于对照组患者的70.00%（35/50）（P＜0.05）。观察组治疗4周后白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）、C反应蛋白（CRP）水平低于对照组（P<0.05）。观察组治疗4周后胃泌素（GAS）低于对照组，胃动素（MTL）高于对照组（P<0.05）。观察组治疗4周后胃蛋白酶原Ⅰ（PGⅠ）、胃蛋白酶原Ⅱ（PGⅡ）水平较对照组更低（P<0.05）。对比两组不良反应发生率无差异（P>0.05）。观察组的Hp根除率为94.00%（47/50），较对照组的72.00%（36/50）更高（P<0.05）。结论：酪酸梭菌活菌胶囊联合四联疗法治疗Hp阳性胃溃疡患者，可取得显著疗效，提高Hp根除率，改善血清炎症因子、胃肠激素和胃蛋酶原亚群，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of clostridium butyricum capsule combined with quadruple therapy on serum inflammatory factors, gastrointestinal hormones and progastrin subsets in patients with Helicobacter pylori (HP) positive gastric ulcer. Methods: 100 cases of HP positive gastric ulcer patients who were admitted in Affiliated Hospital of Tianjin Institute of Traditional Chinese Medicine from February 2017 to March 2020 were selected, they were randomly divided into control group (50 cases, treated with quadruple), observation group (50 cases, treated with clostridium butyricum capsule combined with quadruple) by envelope lottery method. The efficacy, serum inflammatory factors, gastrointestinal hormones, progastrin subsets, Hp eradication rate and adverse reactions of patients in the two groups were compared. Results: After 4 weeks of treatment, the total effective rate of patients in the observation group was 92.00% (46 / 50), which was higher than 70.00% (35 / 50) of patients in the control group (P<0.05). The levels of interleukin-6 (IL-6), tumor necrosis factor -α(TNF-α), procalcitonin (PCT), C-reactive protein (CRP) in the observation group were lower than those of the control group after 4 weeks of treatment (P<0.05). The levels of gastrin (GAS), motilin (MTL) in the observation group were lower than those of the control group after 4 weeks of treatment (P<0.05). The levels of pepsinogen Ⅰ (PG Ⅰ) and pepsinogen Ⅱ (PG Ⅱ) in the observation group were lower than those of the control group after 4 weeks of treatment (P<0.05). There was no difference in incidence rate of adverse reactions between the two groups(P>0.05). The 94.00% (47/50) of Hp eradication rate in the observation group was higher than 72.00% (36/50) of the control group. Conclusion: Clostridium butyricum capsule combined with quadruple therapy in the treatment of Hp positive gastric ulcer patients, can achieve significant curative effect, improve HP eradication rate, improve serum inflammatory factors, gastrointestinal hormones and progastrin subsets, and has good safety. |
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