| 张砚敏,王旭荣,马艳侠,谢晓丽,赵 雅.血清中IL-17和Eotaxin水平检测在支气管哮喘患儿中的应用价值[J].,2020,(23):4556-4560 |
| 血清中IL-17和Eotaxin水平检测在支气管哮喘患儿中的应用价值 |
| Application Value of Detecting Serum IL-17 and Eotaxin Levels in Children with Bronchial Asthma |
| 投稿时间：2020-03-05 修订日期：2020-03-28 |
| DOI：10.13241/j.cnki.pmb.2020.23.034 |
| 中文关键词: 白介素-17 嗜酸性粒细胞趋化因子 肺功能 生活质量 相关性 支气管哮喘 |
| 英文关键词: Interleukin-17 Eosinophil Chemokine Lung Function Quality Of Life Correlation Bronchial Asthma |
| 基金项目:陕西省重点研发计划项目（2108YBXM-SF-12-1） |
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| 中文摘要: |
| 摘要 目的：研究血清中白介素-17（interleukin，IL-17）和嗜酸性粒细胞趋化因子（Eotaxin）水平检测在支气管哮喘患儿中的应用价值。方法：选择2018年1月～2019年12月陕西省中医医院和西安市第一医院的60例支气管哮喘患儿为观察组，其中的18例缓解期患儿为缓解期组，42例急性发作期患儿为急性发作期组，且选择在我院体检的60例健康儿童为对照组。比较缓解期组、急性发作期组患儿和对照组儿童的血清IL-17和Eotaxin水平；比较缓解期组、急性发作期组患儿的一秒钟用力呼气量（forced expiratory volumeat 1st，FEV1）以及最大呼气流量（peak expiratory flow，PEF）和生活质量评分；分析缓解期组、急性发作期组患儿的血清IL-17与Eotaxin的相关性；并分析缓解期组、急性发作期组患儿的血清IL-17、Eotaxin水平与PEF、FEV1和生活质量评分的相关性。结果：缓解期组、急性发作期组患儿的血清IL-17和Eotaxin水平明显高于对照组（P<0.05），且急性发作期组患儿的血清IL-17和Eotaxin水平明显高于缓解期组（P<0.05）；急性发作期组患儿的PEF、FEV1和生活质量评分明显低于缓解期组（P<0.05）；缓解期组、急性发作期组患儿的血清IL-17与Eotaxin之间均呈明显的正相关性（P<0.05）；缓解期组患儿的血清IL-17、Eotaxin水平与PEF、FEV1和生活质量评分均呈明显的负相关性（P<0.05）；急性发作期组患儿的血清IL-17、Eotaxin水平与PEF、FEV1和生活质量评分均呈明显的负相关性（P<0.05）。结论：血清IL-17和Eotaxin在支气管哮喘患儿的发病过程中可以相互影响，共同参与患儿生理病理改变过程，血清IL-17和Eotaxin可作为评估支气管哮喘患儿病情严重程度和生活质量的客观指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the application value of detecting serum IL-17 and Eotaxin levels in children with bronchial asthma. Methods: 60 children with bronchial asthma from January 2018 to December 2019 in Shaanxi Province Traditional Chinese Medicine Hospital and Xi'an First Hospital as the observation group. Among them, 18 children in remission period were in remission period group, 42 children in acute attack period were in acute attack period group, and 60 healthy children who were examined in our hospital were selected as control group. The serum IL-17 and Eotaxin levels of the three groups of children were measured and correlated. Compare the serum IL-17 and Eotaxin levels of children in remission group, acute attack group and control group; compare the PEF, FEV1 and quality of life scores of children in remission group and acute attack group; analyze the remission group, acute Correlation between serum IL-17 and Eotaxin in children in the seizure group; and analysis of the correlation between serum IL-17 and Eotaxin levels in the remission group and acute seizure group with PEF, FEV1 and quality of life scores. Results: The serum IL-17 and Eotaxin levels of the children in the remission period and the acute attack group were significantly higher than those of the control group (P<0.05), and the serum IL-17 and Eotaxin levels of the children in the acute attack group were significantly higher than the remission period (P<0.05). The PEF, FEV1 and quality of life scores of children in the acute attack group were significantly lower than those in the remission group (P<0.05). There was a significant positive correlation between serum IL-17 and Eotaxin in the remission group and acute attack group (P<0.05). Serum IL-17 and Eotaxin levels in the dissolution group were significantly negatively correlated with PEF, FEV1 and quality of life scores (P<0.05). Serum IL-17 and Eotaxin levels in the acute attack group were significantly negatively correlated with PEF, FEV1 and quality of life scores (P<0.05). Conclusion: Serum IL-17 and eotaxin can influence each other and participate in the process of physiological and pathological changes in children with asthma. Serum IL-17 and eotaxin can be used as objective indicators to evaluate the severity and quality of life of children with asthma. |
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