| 王 涛,宋 东,马牧原,赵 阳,叶晓锋.食管癌组织中β-catenin、E-cadherin及MMP-9的表达及其临床意义[J].,2020,(23):4510-4514 |
| 食管癌组织中β-catenin、E-cadherin及MMP-9的表达及其临床意义 |
| Expression and Clinical Significance of β- catenin, E-cadherin and MMP-9 in Esophageal Carcinoma |
| 投稿时间：2020-02-27 修订日期：2020-03-23 |
| DOI：10.13241/j.cnki.pmb.2020.23.024 |
| 中文关键词: 食管癌 β-链蛋白 金属基质蛋白酶-9 E钙黏素 临床病理特征 |
| 英文关键词: Esophageal cancer β-chain protein Metalloproteinase-9 E-cadherin Clinicopathological characteristics |
| 基金项目:宁夏回族自治区卫生厅医疗卫生科研计划项目（20141139） |
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| 中文摘要: |
| 摘要 目的：探讨食管癌组织中β-链蛋白（β-catenin）、E钙黏素（E-cadherin）及金属基质蛋白酶-9（MMP-9）的表达及其临床意义。方法：应用免疫组织化学染色法对60例食管癌患者癌组织和癌旁组织中β-catenin、E-cadherin及MMP-9蛋白表达进行检测，分析其表达与临床病理特征的关系。所有患者随访24个月，观察不同β-catenin、E-cadherin及MMP-9蛋白表达患者的生存情况，并分析食管癌患者癌组织中β-catenin、E-cadherin及MMP-9蛋白表达的相关性。结果：食管患者癌组织中β-catenin及MMP-9蛋白阳性率高于癌旁组织，E-cadherin蛋白阳性率低于癌旁组织（P<0.05）。中低分化、TNM分期为III+IV期、有淋巴结转移者β-catenin及MMP-9蛋白阳性率高于高分化、TNM分期为I+II期、无淋巴结转移者，E-cadherin蛋白阳性率低于高分化、TNM分期为I+II期、无淋巴结转移者（P<0.05）。经Log_rank检验发现，癌组织中β-catenin（-）、E-cadherin（+）、MMP-9（-）患者生存率高于β-catenin（+）、E-cadherin（-）、MMP-9（+）患者（P<0.05）。Spearman相关分析显示，食管癌患者癌组织中β-catenin蛋白表达与E-cadherin蛋白表达呈负相关，与MMP-9蛋白表达呈正相关（P<0.05），MMP-9蛋白表达与E-cadherin蛋白表达呈负相关（P<0.05）。结论：食管癌患者存在β-catenin、MMP-9异常高表达，E-cadherin异常低表达，其表达与食管癌的分化程度、TNM分期、淋巴结转移有关，检测β-catenin、MMP-9、E-cadherin的表达情况有助于预测食管癌患者生存预后。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of β-catenin (β-catenin), E-cadherin (E-cadherin) and matrix metalloproteinase-9 (MMP-9) in esophageal cancer. Methods: Immunohistochemical staining was used to detect the levels of β-catenin, E-cadherin and MMP-9 proteins in cancer and adjacent tissues of 60 patients with esophageal cancer, and the relationship between the expression level and clinicopathological characteristics was analyzed. All patients were followed up for 24 months, the survival of different levels of β-catenin, E-cadherin and MMP-9 were observed. The expression of β-Catenin, E-cadherin and MMP-9 in esophageal cancer were analyzed. Results: The positive rate of β-catenin and MMP-9 protein in esophageal cancer were higher than those in adjacent tissues, and the positive rate of E-cadherin protein was lower than that in adjacent tissues (P<0.05). The positive rates of β-catenin and MMP-9 protein in patients with moderately low differentiation, TNM stage III+IV, lymph node metastasis were higher than those in patients with high differentiation, clinical stage I+II and no lymph node metastasis, and the positive rates of E-cadherin protein were lower than those in patients with high differentiation, clinical stage I+II and no lymph node metastasis (P<0.05). Log_rank test showed that the survival rate of β-catenin (-), E-cadherin (+), MMP-9 (-) patients in cancer tissue were higher than those of β-catenin (+), E-cadherin (-), MMP-9 (-) patients (P<0.05). Spearman correlation analysis showed that the expression of β-catenin protein was negatively correlated with that of E-cadherin protein, and it was positively correlated with that of MMP-9 (P<0.05). The expression of MMP-9 protein was negatively correlated with the expression of E-cadherin protein (P<0.05). Conclusion: The abnormal high expression of β-catenin and MMP-9, and the abnormal low expression of E-cadherin in esophageal cancer patients，which are closely related to the tissue differentiation, TNM stage and lymph node metastasis, the detection of β-catenin, MMP-9 and E-cadherin expression situation are helpful to predict the survival prognosis of esophageal cancer patients. |
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