| 左 俏,孟繁坤,张 嫄,胡 星,刘蔚媛.超声对原发性胆汁性肝硬化合并自身免疫性甲状腺炎的诊断价值和相关性分析[J].,2020,(23):4468-4472 |
| 超声对原发性胆汁性肝硬化合并自身免疫性甲状腺炎的诊断价值和相关性分析 |
| The Value and Correlation of Ultrasonography in the Diagnosis of Primary Biliary Cirrhosis with Autoimmune Thyroiditis |
| 投稿时间：2020-03-23 修订日期：2020-04-17 |
| DOI：10.13241/j.cnki.pmb.2020.23.015 |
| 中文关键词: 超声 原发性胆汁性肝硬化 自身免疫性甲状腺炎 相关性 |
| 英文关键词: Ultrasound Primary biliary cirrhosis Autoimmune thyroiditis Correlation |
| 基金项目:北京市自然科学基金重点项目(7121012) |
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| 中文摘要: |
| 摘要 目的：探讨超声对原发性胆汁性肝硬化合并自身免疫性甲状腺炎的诊断价值以及相关性。方法：选取2017年1月~2019年12月我院收治的90例原发性胆汁性肝硬化合并自身免疫性甲状腺炎患者为研究组，根据患者病情的不同将其分为早期组（n=48）和晚期组（n=42）。另选取50例健康志愿者为对照组，对所有患者进行超声诊断，比较两组患者的门静脉血流参数、肝动脉血流参数、肝中静脉血流参数以及脾静脉血流参数。结果：晚期组的门静脉主干内径（portal vein diameter，PVD）明显高于早期组和对照组（P<0.05），晚期组的平均流速（portal vein velocity，PVV）明显低于早期组和对照组（P<0.05），三组患者的门静脉血流量（perceptual video quality，PVQ）差异无统计学意义（P>0.05）。晚期组的肝动脉内径（hepatic artery inner diameter，HAD）、阻力指数（resistance index，RI）、收缩期峰值流速（peak systolic velocity/end diastolic velocity，HAVmax）、血流量（blood flow，HAQ）均明显大于对照组（P<0.05）。晚期组的肝中静脉内径（middle hepatic vein diameter，MHAD）、最高平均流速（maximum average flow rate ，MHV Vm）、最大血流量（maximum blood flow，MHVQ）均较早期组和对照组减少（P<0.05）。晚期组的脾静脉内径（splenic vein diameter，SVD）明显高于对照组和早期组（P<0.05），晚期组的脾静脉平均流速（splenic vein mean flow rate，SVm）、脾静脉血流量 (splenicveinflow, SVF)与对照组、早期组相比差异无统计学意义（P>0.05）；经过相关性分析肝脏超声指标与甲状腺超声指标均呈现正相关关系（P＜0.05）。结论：超声在原发性胆汁性肝硬化合并自身免疫性甲状腺炎患者中应用具有很高的价值，通过对原发性胆汁性肝硬化超声指标推测自身免疫性甲状腺炎病情程度，患者的超声图像具有一定的特征性，可以用以患者的诊断和病因分析，值得在临床中应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the value and correlation of ultrasonography in the diagnosis of primary biliary cirrhosis with autoimmune thyroiditis. Methods: 90 patients with primary biliary cirrhosis and autoimmune thyroiditis admitted to our hospital from January 2017 to December 2019 were selected as the study group, which was divided into early group (n = 48) and late group (n=42) according to their different conditions. Another 50 healthy volunteers were selected as the control group. All patients were diagnosed by ultrasound. The parameters of portal vein blood flow, hepatic artery blood flow, middle hepatic vein blood flow and spleen vein blood flow were compared between the two groups. Results: The PVD of the late group was significantly higher than that of the early group and the control group (P<0.05), and the PVV of the late group was significantly lower than that of the early group and the control group (P<0.05). There was no significant difference in PVQ (P>0.05). The HAD, RI, HAVmax, and HAQ in the advanced group were significantly larger than those in the control group (P<0.05). The diameter of the MHAD, maximum mean flow velocity (MHV Vm), and blood flow (MHVQ) in the late group were all reduced compared with the early group and the control group (P<0.05). The SVD in the late group was significantly higher than that in the control group and the early group (P<0.05). The SVm and SVF in the late group were different from those in the control group and the early group. No statistical significance (P>0.05); There was a positive correlation between liver ultrasound and thyroid ultrasound (P<0.05). Conclusion: The application of ultrasound in patients with primary biliary cirrhosis and autoimmune thyroiditis is of great value. The degree of autoimmune thyroiditis is estimated by the ultrasound indicators of primary biliary cirrhosis. Characteristics, which can be used for patient diagnosis and etiology analysis, which is worthy of application and promotion in clinical. |
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