| 韩 燚,何金孝,牛焕红,罗建峰,孙 新.糖皮质激素辅助治疗对肺炎支原体肺炎患儿肺功能、血清炎症因子及体液免疫功能的影响[J].,2020,(23):4464-4467 |
| 糖皮质激素辅助治疗对肺炎支原体肺炎患儿肺功能、血清炎症因子及体液免疫功能的影响 |
| Effects of Glucocorticoid on Pulmonary Function, Serum Inflammatory Factors and Humoral Immune Function in Children with Mycoplasma Pneumoniae Pneumonia |
| 投稿时间：2020-02-28 修订日期：2020-03-23 |
| DOI：10.13241/j.cnki.pmb.2020.23.014 |
| 中文关键词: 糖皮质激素 肺炎支原体肺炎 肺功能 炎症因子 体液免疫 |
| 英文关键词: Glucocorticoid Mycoplasma pneumoniae pneumonia Pulmonary function Inflammatory factors Humoral immunity |
| 基金项目:国家自然科学基金青年基金项目（81701487） |
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| 中文摘要: |
| 摘要 目的：探讨糖皮质激素辅助治疗对肺炎支原体肺炎（MPP）患儿肺功能、血清炎症因子及体液免疫功能的影响。方法：选取2016年3月~2019年3月间在我院接受住院治疗的100例MPP患儿，根据随机数字表法将患儿分为研究组、对照组，各50例，其中对照组予以常规治疗，研究组则予以糖皮质激素辅助常规治疗，比较两组患儿临床疗效、肺功能[呼气峰流速值（PEF）、第1s用力呼气容积（FEV1）、潮气量（V-T）]、血清炎症因子[白介素-6（IL-6）、白介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）]及体液免疫功能[免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）]等指标变化情况，记录两组治疗期间不良反应情况。结果：研究组治疗后的临床总有效率为92.00%（46/50），高于对照组的70.00%（35/50）（P<0.05）。治疗后两组患儿IgG、IgA、IgM均较治疗前升高，且研究组高于对照组（P<0.05）。治疗后两组患儿IL-6、IL-10、TNF-α均较治疗前降低，且研究组低于对照组（P<0.05）。治疗后两组患儿PEF、FEV1、V-T均较治疗前升高，且研究组高于对照组（P<0.05）。两组不良反应发生率相比无差异（P>0.05）。结论：糖皮质激素辅助治疗MPP患儿，可减轻机体炎症因子水平，改善患儿肺功能的同时还可缓解体液免疫紊乱，且联合用药安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of glucocorticoid on pulmonary function, serum inflammatory factors and humoral immune function in children with mycoplasma pneumoniae pneumonia (MPP). Methods: From March 2016 to March 2019, 100 children with MPP in our hospital were selected, they were divided into study group and control group according to the random number table method, 50 cases in each group. The control group received routine treatment, while the study group received glucocorticoid assisted routine treatment. The clinical effect, pulmonary function value [peak expiratory flow (PEF), forced expiratory volume in the first second (FEV1), tidal volume (V-T)], serum inflammatory factors [interleukin-6 (IL-6) and interleukin 10 (IL-10), tumor necrosis factor-α (TNF-α)] and humoral immune function [immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG)] indexes changes between two groups were compared. The adverse reactions of the two groups were recorded. Results: The total clinical effective rate of the study group was 92.00% (46/50), which was higher than 70.00% (35/50) of the control group (P<0.05). After treatment, IgG, IgA and IgM of the two groups were higher than before treatment, and those of the study group were higher than those of the control group (P<0.05). After treatment, the levels of IL-6, IL-10 and TNF-α of the two groups were lower than those before treatment, and those of the study group were lower than those of the control group (P<0.05). After treatment, PEF, FEV1 and V-T of the two groups were higher than before treatment, and those of the study group were higher than those of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Glucocorticoid assisted treatment of MPP children can reduce the level of inflammatory factors, improve the lung function of children, but also it can alleviate the disorder of humoral immunity, and the combination of drug safety is better. |
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