| 钟 琦,刘建仁,谭偲艺,邹傲霜,刘 芹.创伤性颅脑损伤患者血清Trx1、FGL2水平与GCS评分及预后的关系研究[J].,2020,(23):4441-4444 |
| 创伤性颅脑损伤患者血清Trx1、FGL2水平与GCS评分及预后的关系研究 |
| Study on the Relationship between Serum Thioredoxin 1 and Fibrin As-is Protein 2 Levels and GCS Score and Prognosis in Patients with Traumatic Craniocerebral Injury |
| 投稿时间：2020-05-29 修订日期：2020-06-23 |
| DOI：10.13241/j.cnki.pmb.2020.23.009 |
| 中文关键词: 创伤性颅脑损伤 硫氧还蛋白1 纤维蛋白原样蛋白2 格拉斯哥昏迷指数 预后 |
| 英文关键词: Traumatic craniocerebral injury Thioredoxin 1 Fibrin original protein 2 Glasgow coma index Prognostic |
| 基金项目:广东省科技计划项目（2016A030303053） |
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| 中文摘要: |
| 摘要 目的：研究创伤性颅脑损伤（TBI）患者血清硫氧还蛋白1（Trx1）、纤维蛋白原样蛋白2（FGL2）水平与格拉斯哥昏迷指数（GCS）评分及预后的关系。方法：将从2017年2月～2019年2月广州中医药大学第一附属医院收治的120例TBI患者纳入研究。将其按照入院即刻GCS评分分成轻度组（13～15分）46例，中度组（9～12分）38例，重度组（3～8分）36例。另取同期于广州中医药大学第一附属医院进行体检的健康志愿者40例作为对照组。比较各组人员血清Trx1以及FGL2水平，并作相关性分析。此外，将重度组患者按照预后结果的不同分成死亡组以及存活组。比较两组血清Trx1以及FGL2水平，以受试者工作特征（ROC）曲线分析血清Trx1以及FGL2对重度TBI患者预后的预测价值。结果：轻度组、中度组及重度组患者的血清Trx1水平均低于对照组，且重度组低于中度组，中度组又低于轻度组（P＜0.05）；轻度组、中度组及重度组患者的血清FGL2水平均高于对照组，且重度组高于中度组，中度组又高于轻度组（P＜0.05）。经Pearson相关性分析可得：TBI患者血清Trx1水平与GCS评分呈正相关关系（r/P=0.554/0.001），而血清FGL2水平与GCS评分呈负相关关系（P＜0.05）。死亡组患者血清Trx1水平低于存活组（P＜0.05），而FGL2水平高于存活组（P＜0.05）。经ROC曲线分析发现：血清Trx1联合FGL2预测重度TBI患者预后的曲线下面积、敏感度以及特异度均高于上述两项指标单独检测。结论：Trx1以及FGL2在TBI患者血清中存在明显的异常表达，且与GCS评分相关，可能作为临床TBI诊断、病情判断以及预后评估的辅助生物学标志物。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between serum thioredoxin 1 (Trx1) and fibrin original protein 2 (FGL2) levels, Glasgow coma index (GCS) score and prognosis in patients with traumatic brain injury (TBI). Methods: 120 TBI patients who were admitted to the The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from February 2017 to February 2019 were included in the study. According to the GCS score immediately after admission, they were divided into mild group (13 ~ 15 points) with 46 cases, moderate group (9 ~ 12 points) with 38 cases, and severe group (3 ~ 8 points) with 36 cases. Another 40 healthy volunteers who underwent physical examination in the first affiliated hospital of Guangzhou university of traditional Chinese medicine at the same time were selected as the control group. The serum Trx1 and FGL2 levels in each group were compared and the correlation was analyzed. In addition, patients in the severe group were divided into the death group and the survival group according to the different prognosis. The serum Trx1 and FGL2 levels in the two groups were compared, and the predictive value of serum Trx1 and FGL2 in patients with severe TBI was analyzed by receiver operating characteristic (ROC) curve. Results: The serum Trx1 level in the mild group, moderate group and severe group were lower than that in the control group, and the severe group was lower than that in the moderate group, while the moderate group was lower than that in the mild group (P＜0.05). The serum FGL2 level of patients in the mild group, moderate group and severe group were higher than that in the control group, and the severe group was higher than that in the moderate group, while the moderate group was higher than that in the mild group (P＜0.05). Pearson correlation analysis showed that serum Trx1 level in TBI patients was positively correlated with GCS score (P＜0.05), while serum FGL2 level was negatively correlated with GCS score (P＜0.05). Serum Trx1 level of patients in the death group was lower than that of the survival group (P＜0.05), while FGL2 level was higher than that of the survival group (P＜0.05). ROC curve analysis showed that the area under the curve, the sensitivity and the specificity of serum Trx1 combined with FGL2 in predicting the prognosis of severe TBI patients were all higher than those measured separately. Conclusion: Trx1 and FGL2 have obvious abnormal expression in serum of TBI patients, which are related to GCS score, and may be used as an assistant biomarker for early diagnosis, disease diagnosis and prognosis assessment of clinical TBI. |
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