| 徐蕾蕾,华 馥,李长华,周树林,徐 童.上皮性卵巢癌组织miR-338-3p、miR-1294的表达及临床意义[J].,2020,(22):4293-4297 |
| 上皮性卵巢癌组织miR-338-3p、miR-1294的表达及临床意义 |
| The Expressions and Clinical Significance of miR-338-3p, miR-1294 in Patients with Epithelial Ovarian Cancer |
| 投稿时间：2020-05-07 修订日期：2020-05-31 |
| DOI：10.13241/j.cnki.pmb.2020.22.020 |
| 中文关键词: 上皮性卵巢癌 miR-338-3p miR-1294 预后 临床病理参数 |
| 英文关键词: Epithelial ovarian cancer miR-338-3p miR-1294 Prognosis Clinicopathological characteristics |
| 基金项目:国家自然科学基金面上项目（81472442） |
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| 中文摘要: |
| 摘要 目的：探讨上皮性卵巢癌组织中微小RNA（miR）-338-3p、miR-1294表达与患者临床病理参数的关系，并分析其表达对上皮性卵巢癌预后的影响。方法：收集2010年6月～2015年6月我院行手术治疗的上皮性卵巢癌患者的石蜡组织样本（癌组织和癌旁正常组织），实时荧光定量PCR（RT-PCR）技术检测组织样本中miR-338-3p、miR-1294的表达情况；分析癌组织中miR-338-3p、miR-1294表达与患者临床病理参数的关系；Kaplan-Meier生存曲线分析miR-338-3p、miR-1294表达与患者预后的关系；Cox回归模型分析上皮性卵巢癌患者的预后影响因素。结果：与癌旁正常组织相比，上皮性卵巢癌组织中miR-338-3p、miR-1294表达均降低（均P<0.05）；miR-338-3p表达与组织学分级、淋巴结转移、FIGO分期相关（均P<0.05）；miR-1294表达与肿瘤直径、淋巴结转移、FIGO分期相关（均P<0.05）。Kaplan-Meier生存曲线结果显示，miR-338-3p低表达组患者、miR-1294低表达组患者的预后较差（均P<0.05）。Cox回归模型分析结果显示，淋巴结转移、较高FIGO分期、miR-338-3p低表达、miR-1294低表达是上皮性卵巢癌预后的危险因素（均P<0.05）。结论：上皮性卵巢癌组织中miR-338-3p、miR-1294均低表达，且均与较差临床病理参数、预后不良相关；miR-338-3p、miR-1294可能是上皮性卵巢癌患者预后预测的潜在指标。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between microRNA (miR)-338-3p, miR-1294 expression with the clinicopathological parameters in epithelial ovarian cancer tissues, and to analyze their impact on the prognosis in epithelial ovarian cancer. Methods: Paraffin tissue samples (cancer tissue and normal tissue adjacent to cancer) of epithelial ovarian cancer patients in our hospital from June 2010 to June 2015 were collected, real-time quantitative PCR (RT-PCR) was used to detect the expression of miR-338-3p and miR-1294 in tissue samples. The correlation between the miR-338-3p, miR-1294 expression with the clinicopathological characteristics were analyzed. The Kaplan Meier survival curve was used to analyze the relation of miR-338-3p, miR-1294 expression with the prognosis of patients. The Cox regression model was used to analyze the influence factors of prognosis. Results: Compared to the adjacent normal tissues, the miR-338-3p and miR-1294 expression were both down-regulated in the cancer tissues (all P<0.05). The miR-338-3p expression were related with histological grade, lymph node metastasis and the FIGO stage (all P<0.05). The miR-1294 expression were related with tumor diameter, lymph node metastasis and the FIGO stage (all P<0.05). Kaplan Meier survival curve results showed the prognosis of patients with miR-338-3p low expression and miR-1294 low expression were poorer (all P<0.05). Cox regression model analysis results showed that the lymph node metastasis, higher FIGO staging, miR-338-3p low expression and miR-1294 low expression were the risk factors for the prognosis (all P<0.05). Conclusion: In epithelial ovarian cancer, the miR-338-3p and the miR-1294 are all low expression, which are related to worse clinicopathological parameters and poorer prognosis. The miR-338-3p and miR-1294 may be potential prognostic indicators for patients with epithelial ovarian cancer. |
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