| 王旭荣,刘柳叶,张北宁,韩丽丽,王 军.血清cTnI、CK-MB及IGF-1在新生儿高胆红素血症中的变化及临床意义[J].,2020,(21):4101-4104 |
| 血清cTnI、CK-MB及IGF-1在新生儿高胆红素血症中的变化及临床意义 |
| Changes of Serum cTnI, CK-MB and IGF-1 in Neonatal Hyperbilirubinemia and Its Clinical Significance |
| 投稿时间：2020-04-03 修订日期：2020-04-27 |
| DOI：10.13241/j.cnki.pmb.2020.21.022 |
| 中文关键词: 高胆红素血症 新生儿 胰岛素样生长因子-1 |
| 英文关键词: Hyperbilirubinemia Newborn Insulin-like growth factor-1 |
| 基金项目:陕西省重点研发计划项目(2108YBXM-SF-12-1) |
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| 中文摘要: |
| 摘要 目的：分析血清肌钙蛋白T( troponin T，cTnT)、肌酸激酶同工酶(creatine kinase isoenzyme，CK-MB)及胰岛素样生长因子-1(insulin-like growth factor-1，IGF-1)在新生儿高胆红素血症中变化及临床价值。方法：选择2015年1月至2019年12月我院新生儿科收治的80例新生儿高胆红素血症足月新生儿(观察组)以及80例非胆红素足月新生儿(对照组)为研究对象。收集住院资料，包括所有患儿的胎龄、日龄、出生体重、血清总胆红素（total bilirubin，TBIL）、CK-MB、cTnT、IGF-1、头颅核磁共振(skull magnetic resonance，MRI)、临床表现等及出院后随访资料。根据胆红素水平高低，将观察组分为轻度(33例)、中度组(27例)及重度组(20例)，比较其：TBIL、IGF-1、CK-MB、cTnT水平。结果：各组新生儿TBIL、CK-MB、cTnT水平比较差异具有统计学意义(P＜0.05)。重度黄疸组TBIL、CK-MB、cTnT值分别高于轻度、中度黄疸组和对照组，IGF-1低于轻度、中度黄疸组和对照组(P＜0.05)；中度黄疸组TBIL、CK-MB、cTnT高于轻度黄疸组和对照组，IGF-1低于轻度黄疸组和对照组(P＜0.05)；轻度黄疸组TBIL、CK-MB、cTnT高于对照组，IGF-1低于对照组(P＜0.05)。血清cTnT与TBIL水平呈正相关(r=0.587，P＜0.05)；血清CK-MB与TBIL水平无明显相关性(r=0.220，P＞0.05)；血清IGF-1与TBIL水平呈负相关（r=-0.568，P＜0.05）。苍白球异常信号组患儿血清IGF-1值为(11.05±0.51) ng/mL，明显低于苍白球正常信号组(14.22±2.67) ng/mL(P＜0.05)；苍白球异常信号组患儿血清TBIL水平为(347.62±33.01)μmol/L与苍白球正常信号组(341.75±35.14)μmol/L无明显差别(P＞0.05)。结论：检测血清cTnT和IGF-1水平分别有助于预测新生儿高胆红素血症心肌损伤和脑病的发生。 |
| 英文摘要: |
| ABSTRACT Objective: The changes and clinical value of serum cTnI, CK-MB and IGF-1 in neonatal hyperbilirubinemia were analyzed. Methods: Eighty neonatal hyperbilirubinemia full-term neonates (observation group) and 80 non-bilirubin full-term neonates (control group) who were treated in the neonatal department to our hospital from January 2015 to December 2019 were selected as studies. Collected hospitalization data, including gestational age, age, birth weight, total serum bilirubin value, CK-MB, cTnT, and IGF-1, skull magnetic resonance, clinical manifestations, and follow-up data after discharge for all children. According to the level of bilirubin, the observation components were divided into mild group (33 cases), moderate group (27 cases), and severe group (20 cases), and their levels were compared: TBIL, IGF-1, CK-MB, cTnT levels. Results: The differences of TBIL, CK-MB and cTnT levels of neonates in each group were statistically significant (P<0.05). The TBIL, CK-MB and cTnT values in the severe jaundice group were higher than those in the mild, moderate jaundice group and the control group, while IGF-1 was lower than that in the mild, moderate jaundice group and the control group (P<0.05). The moderate jaundice group TBIL, CK-MB, cTnT were higher than mild jaundice group and control group, IGF-1 was lower than mild jaundice group and control group (P<0.05). TBIL, CK-MB, cTnT in mild jaundice group were higher than control group , IGF-1 was lower than the control group (P<0.05). Serum cTnT was positively correlated with TBIL levels (r=0.587, P<0.05). Serum CK-MB was not significantly correlated with TBIL levels (r=0.220, P>0.05); serum IGF-1 was negatively correlated with TBIL levels (r=-0.568, P<0.05). The serum IGF-1 value of children with abnormal globus pallidus signal group was (11.05±0.51) ng/mL, which was significantly lower than that of normal globus pallidus signal group (14.22±2.67) ng/mL (P<0.05). The serum TBIL level of children was (347.62±33.01) μmol/L and pallor normal signal group (341.75±35.14) μmol/L was not significantly different (P>0.05). Conclusion: Detection of serum cTnT and IGF-1 levels could help predict the occurrence of neonatal hyperbilirubinemia myocardial injury and encephalopathy. |
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