| 柳 俊,陈 军,鲍 晨,陈进娜,董学敏,陈粉婷.HSP70、eIF4E、DNMT1在宫颈癌中的表达及意义[J].,2020,(20):3988-3991 |
| HSP70、eIF4E、DNMT1在宫颈癌中的表达及意义 |
| Expression and Significance of HSP70, eIF4E and DNMT1 in Cervical Cancer |
| 投稿时间：2020-05-07 修订日期：2020-05-31 |
| DOI：10.13241/j.cnki.pmb.2020.20.041 |
| 中文关键词: 宫颈癌 热休克蛋白70 真核细胞翻译起始因子4E DNA甲基转移酶1 |
| 英文关键词: Cervical cancer Heat shock protein 70 Eukaryotic cell translation initiation factor 4E DNA methyltransferase 1 |
| 基金项目:陕西省科学技术计划项目(NO.2015SF257) |
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| 中文摘要: |
| 摘要 目的：探讨热休克蛋白70（HSP70）、真核细胞翻译起始因子4E（eIF4E）、DNA甲基转移酶1（DNMT1）在宫颈癌中的表达及意义。方法：选择2015年2月至2017年2月我院接诊的40例女性宫颈癌患者为本研究对象，收集所有患者手术切除病理组织制作石蜡切片，并选择我院同期接受其他手术的35例标本作为对照组，使用SP免疫组织化学法观察乳腺癌组织中HSP70、eIF4E、DNMT1染色结果，并分析其和临床病理因素之间的关系。结果：在免疫组化学法结果中显示，40例宫颈癌组织中，HSP70阳性表达率为65.00%（26/40），eIF4E阳性表达率为67.50%（27/40），DNMT1阳性表达率为72.50%（29/40），均显著高于对照组（P＜0.05）；在宫颈癌组织中，HSP70、eIF4E、DNMT1和分化程度、临床分期及淋巴转移均有密切关系，（P＜0.05）；将分化程度、临床分期、淋巴转移、HSP70、eIF4E、DNMT1进行相关分析，结果显示，HSP70、eIF4E、DNMT1和分化程度、临床分期及淋巴转移之间均呈正相关（P＜0.05），且HSP70和eIF4E、DNMT1均呈正相关（P＜0.05），eIF4E和DNMT1呈正相关（P＜0.05）。结论：在宫颈癌组织中HSP70、eIF4E、DNMT1的高表达和临床病理之间存在着密切关系。 |
| 英文摘要: |
| ABSTRACT Objective: To study Expression and significance of Heat shock protein 70 (HSP70), eukaryotic translation initiation factor 4E (eIF4E), DNA methyltransferase 1 (DNMT1) in cervical cancer. Methods: 40 female cervical cancer patients admitted to our hospital from February 2015 to February 2017 were selected as the subjects of this study, all patients were collected for the preparation of paraffin sections after surgical resection of pathological tissues, and 35 specimens received other surgeries in our hospital were selected as the control group. The staining results of HSP70, eIF4E and DNMT1 in breast cancer tissues were observed using SP immunohistochemical method, and the relationship between them and clinicopathological factors was analyzed. Results: According to the results of immunohistochemistry, the positive expression rate of HSP70 was 65.00% (26/40), eIF4E was 67.50% (27/40), and DNMT1 was 72.50% (29/40), all significantly higher than the control group (P<0.05). In cervical cancer tissues, HSP70, eIF4E, DNMT1 were closely correlated with the degree of differentiation, clinical stage and lymphatic metastasis (P<0.05). The correlation analysis of differentiation degree, clinical stage, lymphatic metastasis, HSP70, eIF4E and DNMT1 showed that there was a positive correlation between HSP70, eIF4E, DNMT1 and differentiation degree, clinical stage and lymphatic metastasis (P<0.05), and there was a positive correlation between HSP70, eIF4E and DNMT1 (P<0.05), and there was a positive correlation between eIF4E and DNMT1 (P<0.05). Conclusion: There is a close relationship between the high expression of HSP70, eIF4E and DNMT1 in cervical cancer tissues and the clinicopathology, which can promote the disease progression, and this study also provides a new idea for the targeted drug treatment of cervical cancer. |
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