| ABSTRACT Objective: To investigate the bone metabolism of middle-aged and elderly men with type 2 diabetes at different ages. Methods: 203 middle-aged and elderly male patients with type 2 diabetes were recruited and divided into three groups: 50≤group A＜60, 60≤group B＜70, 70≤group C≤80. Anthropometric measurements include: BMI, WC, SDP, DBP, HbA1c, FPG, TG, HDL-c, OC, P1NP, CTX, BMD. Results: OC and P1NP of group C were decreased than group A and group B, While CTX of group C was increased than group A and group B. The diabetes duration of group C was longer than group A and group B, while the diabetes duration of group B was longer than group A. BMD of femoral neck in group B and group C were decreased than group A. BMD of L4 in group C was decreased than group A and group B (P<0.05). HbA1c and BMD values of femoral neck, femoral shaft, total hip, L1, L2, L3 and L4 were not significantly different among the three groups (P>0.05). Correlation analysis showed that age was positively correlated with duration of diabetes (R=0.284, P<0.001) and BMI (R=0.193, P=0.007). OC was positively correlated with P1NP (R=0.465, P<0.001), negatively correlated with CTX(R=-0.312, P=0.002), duration of diabetes (R=-0.264, P<0.001), BMI(R=-0.425, P<0.001). P1NP was negatively correlated with CTX(R=-0.341, P< 0.001), duration of diabetes (R=-0.206, P=0.004), BMI (R=-0.468, P<0.001). CTX was positively correlated with the duration of diabetes (R=0.171, P=0.017) and BMI (R=0.443, P<0.001). Conclusion: In middle-aged and elderly male patients with type 2 diabetes, bone metabolism indexes are correlated with BMI and diabetes course, but not with age. |
