| 赵子洲,莫 煊,郑银佳,孔雪燕,陈永源.首发抑郁症患者血清成纤维细胞生长因子22、胶质纤维酸性蛋白水平及其临床意义[J].,2020,(20):3902-3906 |
| 首发抑郁症患者血清成纤维细胞生长因子22、胶质纤维酸性蛋白水平及其临床意义 |
| Levels of Serum Fibroblast Growth Factor-22 and Glial Fibrillary Acidic Protein in Patients with First-episode Depression and Its Clinical Significance |
| 投稿时间：2020-02-21 修订日期：2020-03-16 |
| DOI：10.13241/j.cnki.pmb.2020.20.022 |
| 中文关键词: 首发抑郁症 成纤维细胞生长因子22 胶质纤维酸性蛋白 执行功能 |
| 英文关键词: First-episode depression Fibroblast growth factor-22 Glial fibrillary acidic protein Performing function |
| 基金项目:广东省医学科研基金项目（B20171269）；广州市医药卫生科技项目(2018A011089) |
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| 中文摘要: |
| 摘要 目的：检测首发抑郁症患者血清中成纤维细胞生长因子22（FGF-22）和胶质纤维酸性蛋白（GFAP）水平，并探讨其临床意义。方法：选取2018年2月至2019年2月我院就诊并住院的首发抑郁症患者40例（抑郁症组）和体检中心的健康体检人员40例（健康对照组）作为研究对象，采用酶联免疫吸附试验检测研究对象血清中的FGF-22和GFAP水平，采用汉密尔顿抑郁量表（HAMD-17）评价研究对象的抑郁症状，采用威斯康星卡片分类测验（WCST）测试研究对象的执行功能，采用Pearson积矩相关系数分析血清FGF-22和GFAP水平与HAMD-17评分及执行功能的关系，采用受试者工作特征（ROC）曲线评估FGF-22、GFAP的诊断价值。结果：抑郁症组患者血清GFAP水平、HAMD-17评分、WCST持续错误数和随机错误数显著高于健康对照组（P<0.05），血清FGF-22水平、WCST正确应答数和完成分类数显著低于健康对照组（P<0.05）。抑郁症组患者血清FGF-22浓度与WCST正确应答数和完成分类数呈正相关（P<0.05），与HAMD -17评分、WCST持续错误数和随机错误数呈负相关（P<0.05）；抑郁症组患者血清GFAP水平与WCST正确应答数和完成分类数呈负相关（P<0.05），与HAMD-17评分、WCST持续错误数和随机错误数呈正相关（P<0.05）。ROC曲线分析显示，FGF-22诊断首发抑郁症的最佳界点为194.3 ng/mL，诊断灵敏度和特异度分别为87.5%和72.5%，ROC曲线下面积(AUC)为0.848（95%的置信区间为0.755-0.941）；GFAP诊断首发抑郁症的最佳界点为1128 ng/L，诊断敏感度和特异度分别为80.0%和85.0%，AUC为0.866（95%的置信区间为0.785-0.948）。结论：首发抑郁症患者血清FGF-22和GFAP水平与患者抑郁严重程度和执行功能损害有关。 |
| 英文摘要: |
| ABSTRACT Objective: To measured the levels of serum fibroblast growth factor-22 (FGF-22) and glial fibrillary acidic protein (GFAP) in patients with first-episode depression, and to explore its clinical significance. Methods: From February 2018 to February 2019, 40 first-episode depression patients (depression group) treated in our hospital and 40 health checkers (health control group) in the physical examination center were selected as the study objects. The levels of FGF-22 and GFAP in the serum of the subjects were detected by enzyme-linked immunosorbent assay. The Hamilton Depression Scale (HAMD-17) was used to evaluate the severity of depression. The Wsiconsin Card Sorting Test (WCST) was used to test the performing function. We used Pearson product-moment correlation to evaluate the relationship between serum FGF-22, GFAP levels and HAMD-17 scores and performing function. The diagnostic value of the two factors was evaluated by receiver operating characteristic (ROC) curve. Results: Serum GFAP levels, HAMD-17 scores, WCST perseverative errors and random errors in the depression group were significantly higher than the healthy control group (P<0.05). Serum FGF-22 levels, WCST correct response, and categories completed in the depression group were significant lower than the healthy control group (P<0.05). The serum FGF-22 concentration in the depression group was positively correlated with the correct responses and the categories completed (P<0.05), and negatively correlated with HAMD-17 scores, WCST perseverative errors, and random errors (P<0.05); The GFAP level in the depression group was negatively correlated with the WCST correct responses and the categories completed (P<0.05), and positively correlated with HAMD-17 scores, WCST perseverative errors, and random errors (P<0.05). ROC curve analysis display, the best borderline of FGF-22 in the diagnosis of first-episode depression was 194.3 ng/ml. the sensitivity and specificity of FGF-22 were 87.5% and 72.5% respectively, the area under curve was 0.848 (95%CI 0.755-0. 941). The best borderline of GFAP in the diagnosis of first-episode depression was 1128 ng/L, the sensitivity and specificity were 80.0% and 85.0% respectively, and the area under curve was 0.866 (95%CI 0.785-0.948). Conclusion: Serum FGF-22 and GFAP levels in patients with first-episode depression are related to the severity of depression and performing function impairment. |
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