| 李心蕾,经博文,封学伟,郑 智,张雪艳,王 娟.调经促孕丸联合奥利司他治疗肥胖型多囊卵巢综合征不孕的临床研究[J].,2020,(20):3845-3848 |
| 调经促孕丸联合奥利司他治疗肥胖型多囊卵巢综合征不孕的临床研究 |
| Clinical Study on the Treatment of Obesity Polycystic Ovary Syndromeinfertility with Tiaojing Cuyun Pill and Orlistat |
| 投稿时间：2020-05-03 修订日期：2020-05-27 |
| DOI：10.13241/j.cnki.pmb.2020.20.009 |
| 中文关键词: 调经促孕丸 奥利司他 肥胖型 多囊卵巢综合征 不孕 疗效 |
| 英文关键词: Tiaojing Cuyun pill Orlistat Obesity Polycystic ovary syndrome Infertility Curative effect |
| 基金项目:北京市自然科学基金项目（7092039） |
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| 中文摘要: |
| 摘要 目的：探讨调经促孕丸联合奥利司他治疗肥胖型多囊卵巢综合征（PCOS）不孕的临床疗效。方法：选取2017年6月到2019年8月期间我院收治的肥胖型PCOS不孕患者120例，按照随机数字表法将患者分为对照组（n=60）和研究组（n=60）。对照组予以奥利司他治疗，研究组在对照组的基础上联合调经促孕丸治疗，比较两组患者疗效、激素水平、排卵率、妊娠率、血糖及不良反应。结果：研究组治疗3个疗程后的临床总有效率为90.00%（54/60），高于对照组的70.00%（42/60）（P<0.05）。两组治疗3个疗程后睾酮（T）、卵泡刺激素（FSH）、促黄体生成素（LH）均较治疗前下降，且研究组低于对照组（P<0.05）。研究组的排卵率为85%（51/60）、妊娠率为65%（39/60）均高于对照组的65%（39/60）、46.67%（28/60）（P<0.05）。两组餐后2 h血糖(2hPG)、空腹血糖（FBG）、糖化血红蛋白（HbAlc）均较治疗前下降，且研究组低于对照组（P<0.05）。两组治疗期间不良反应发生率对比未见统计学差异（P>0.05）。结论：调经促孕丸联合奥利司他治疗肥胖型PCOS不孕患者，疗效显著，可有效改善患者激素水平、血糖、排卵率、妊娠率，且不增加不良反应发生率。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of Tiaojing Cuyun pill combined with orlistat in the treatment of obesity polycystic ovary syndrome (PCOS) infertility. Methods: 120 obese patients with PCOS infertility who were treated in our hospital from June 2017 to August 2019 were selected, they were divided into control group (n=60) and study group (n=60) according to the method of random number table. The control group was treated with orlistat, and the study group was treated with Tiaojing Cuyun Pill on the basis of the control group. Results: The total effective rate of the study group at three courses after treatment was 90.00% (54/60), which was higher than 70.00% (42/60) of the control group (P<0.05). Testosterone (T), follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the two groups decreased at three courses after treatment, and the level in the study group was lower than that in the control group (P<0.05). The ovulation rate and pregnancy rate of the study group were 85% (51/60) and 65% (39/60) respectively, which were higher than 65% (39/60) and 46.67% (28/60) of the control group (P<0.05). Two hours postprandial blood glucose (2hPG), fasting blood glucose (FBG) and glycosylated hemoglobin (HbAlc) of the two groups were lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups during the treatment(P>0.05). Conclusion: Tiaojing Cuyun pill combined with orlistat can effectively improve the hormone level, blood sugar, ovulation rate and pregnancy rate of obese PCOS patients without increasing the incidence of adverse reactions. |
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