| 王 飞,胡方启,王 乐,何 平,王宁玲.益生菌联合三联疗法治疗小儿幽门螺杆菌相关性胃炎的疗效及对炎性因子的影响[J].,2020,(19):3797-3800 |
| 益生菌联合三联疗法治疗小儿幽门螺杆菌相关性胃炎的疗效及对炎性因子的影响 |
| The Effect of Probiotics Combined with Triple Therapy on Helicobacter Pylori Related Gastritis in Children and Its Influence on Inflammatory Factors |
| 投稿时间：2019-12-31 修订日期：2020-01-25 |
| DOI：10.13241/j.cnki.pmb.2020.19.043 |
| 中文关键词: 益生菌 三联疗法 儿童 幽门螺杆菌 胃炎 疗效 炎性因子 |
| 英文关键词: Probiotics Triple therapy Children Helicobacter pylori Gastritis Efficacy Inflammatory factors |
| 基金项目:安徽省科技厅科研基金项目（15070404051） |
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| 中文摘要: |
| 摘要 目的：探讨益生菌联合三联疗法治疗小儿幽门螺杆菌（HP）相关性胃炎的疗效及对炎性因子的影响。方法：选取2017年1月~2018年6月期间我院收治的HP相关性胃炎患儿93例，根据乱数表法将患儿分为研究组（n=47）、对照组（n=46），对照组患儿给予三联疗法治疗，研究组在对照组的基础上联合益生菌治疗，比较两组患儿临床疗效、临床症状总评分、炎性因子、HP根除率、不良反应发生率及复发率。结果：治疗1个月后，研究组的临床总有效率为87.23%（41/47），高于对照组的69.57%（32/46）（P<0.05）。两组治疗2周后、1个月后的临床症状总评分及治疗1个月后血清肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）、白介素-6（IL-6）水平均下降（P＜0.05），且研究组低于对照组（P<0.05）。研究组HP根除率高于对照组（P<0.05）。两组不良反应发生率及复发率比较无差异（P>0.05）。结论：益生菌联合三联疗法治疗小儿HP相关性胃炎的疗效确切，可改善患儿的临床症状，降低炎性因子水平，且用药安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of probiotics combined with triple therapy on Helicobacter pylori (HP) - related gastritis in children and its influence on inflammatory factors. Methods: 93 cases of HP related gastritis in our hospital from January 2017 to June 2018 were selected, and they were divided into study group (n=47) and control group (n=46) according to the method of random number table. The control group was treated with triple therapy. The study group was treated with probiotics on the basis of the control group, the clinical effect, total score of clinical symptoms, inflammatory factors, HP eradication rate, incidence and recurrence of adverse reactions were compared. Results: After 1 month treatment, the total clinical effective rate of the study group was 87.23% (41/47), which was higher than 69.57% (32/46) of the control group (P<0.05). The total score of clinical symptoms after 2 weeks and 1 month treatment and the levels of serum tumor necrosis factor-α (TNF-α), hypersensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6) after 1 month treatment of the two groups decreased (P<0.05), and those of the study group were lower than those of the control group (P<0.05). The eradication rate of HP of the study group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions and recurrence rate between the two groups (P>0.05). Conclusion: The curative effect of probiotics combined with triple therapy in the treatment of HP related gastritis in children is definite, which can improve the clinical symptoms and reduce the level of inflammatory factors with good drug safety in children. |
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