| 黄 波,刘耀华,金瑞日,李 森,李 勇.WBSCR22在脑胶质瘤中的表达与临床病理特征及预后关系[J].,2020,(19):3668-3672 |
| WBSCR22在脑胶质瘤中的表达与临床病理特征及预后关系 |
| Expression of WBSCR22 in Gliomas and Its Relationship with Clinicopathological Features and Prognosis |
| 投稿时间：2020-03-28 修订日期：2020-04-23 |
| DOI：10.13241/j.cnki.pmb.2020.19.013 |
| 中文关键词: WBSCR22 胶质瘤 临床 病理 |
| 英文关键词: WBSCR22 Glioma Clinical Pathology |
| 基金项目:国家自然科学基金项目（81372701） |
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| 中文摘要: |
| 摘要 目的：探索WBSCR22在脑胶质瘤中的表达及与临床病理特征和预后的关系。方法：通过生物信息学数据库，分析WBSCR22表达与脑胶质瘤生存的关系、在不同种族脑胶质瘤表达差异。通过免疫组织化学法检测WBSCR22在171例脑胶质瘤组织芯片中的表达，分析其与脑胶质瘤患者临床病理特征及总生存期的关系。结果：生物信息学分析显示脑胶质瘤WBSCR22表达高的患者生存期较表达低的患者短（P<0.05）。亚洲人群脑胶质瘤中WBSCR22表达较高加索人、非洲人种表达升高（P<0.05）。组织芯片学结果显示：不同肿瘤分级、复发与否的脑胶质瘤患者WBSCR22的表达存在差异，差异具有统计学意义（P<0.05）。不同性别、年龄患者脑胶质瘤细胞 WBSCR22表达率比较，差异无统计学意义（P＞0.05）WBSCR22高表达患者的总生存期明显短于WBSCR22低表达患者的总生存期（P<0.01）。结论：WBSCR22在亚洲人群脑胶质瘤中表达较高，其表达水平与肿瘤分级相关，且脑胶质瘤细胞WBSCR22表达水平越高，总生存期越短。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression of WBSCR22 in gliomas and its relationship with clinicopathological features and prognosis. Methods: Bioinformatics database was used to analyze the relationship between the expression of WBSCR22 and the survival of gliomas and the difference of expression in different races of gliomas. The expression of WBSCR22 in 171 cases of glioma tissue microarray was detected by immunohistochemical method, and its relationship with clinicopathological features and overall survival time of glioma patients was analyzed. Results: Bioinformatics analysis showed that the survival time of patients with high expression of WBSCR22 in gliomas was shorter than that of patients with low expression of Glioma（P<0.05）. The expression of WBSCR22 in Asian gliomas was higher than that in Caucasians and Africans. The results of histological chip showed that there were significant differences in the expression of WBSCR22 in glioma patients with different tumor grades and recurrent or not. There was no significant difference in the expression rate of cytoplasmic WBSCR22 in gliomas of different genders and ages（P＞0.05）. The overall survival time of patients with high expression of WBSCR22 was significantly shorter than that of patients with low expression of WBSCR22 (P<0.01). Conclusion: The expression of WBSCR22 is higher in Asian gliomas, and its expression level is related to tumor grade, and the higher the expression level of WBSCR22 in glioma cells is, the shorter the overall survival time is. |
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