| 张达衡,柯 玲,曾海莲,陈红玲,侯舒倩.绝经期女性阴道微生态状况及发生生殖道萎缩程度的相关性[J].,2020,(18):3567-3571 |
| 绝经期女性阴道微生态状况及发生生殖道萎缩程度的相关性 |
| Correlation between Vaginal Microecological Status and Reproductive Tract Atrophy in Postmenopausal Women |
| 投稿时间：2020-03-25 修订日期：2020-04-15 |
| DOI：10.13241/j.cnki.pmb.2020.18.038 |
| 中文关键词: 绝经期女性 阴道微生态状况 生殖道萎缩程度 相关性 |
| 英文关键词: Postmenopausal women Vaginal microecology Degree of genital tract atrophy Correlation |
| 基金项目:广东省科技计划项目（2013B022000007） |
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| 中文摘要: |
| 摘要 目的：评估绝经期女性阴道微生态状况，分析其与发生生殖道萎缩程度的相关性。方法：回顾性分析2015~2018年于本院妇科门诊就诊的120例绝经期女性患者的临床资料，获取所有患者阴道分泌物清洁度，优势菌群种类、密集度、多样性，阴道pH值、H2O2、白细胞酯酶、唾液酸苷酶，阴道假丝酵母菌病(VVC)、滴虫性阴道炎(TV)、细菌性阴道病(BV)、需氧菌性阴道病(AV)阳性率；采用相关统计资料分析阴道微生态状态与发生生殖道萎缩相关性。结果：绝经期女性阴道清洁度Ⅲ/Ⅳ度占比70%、Ⅰ/Ⅱ度占比30%；优势菌群以G染色不定球杆菌、G-大杆菌为主，G-小杆菌较少；菌群密集度、多样性程度较高；PH值为>4.5占比70%，提示阴道环境处于中性/碱性状态居多；H2O2、白细胞酯酶、唾液酸苷酶、VVC、BV阳性占比高而TV、AV阳性占比低。清洁度Ⅰ/Ⅱ度、菌群密集度+++/++++、菌群多样性+++/++++、PH值3.8~4.5、H2O2 (-)、唾液酸苷酶(-)、VVC(-)、BV(-/中介)时阴道萎缩发生率低于清洁度Ⅲ/Ⅳ度、菌群密集度未见/+、菌群多样性未见/+、pH值>4.5、H2O2 (+)、唾液酸苷酶(+)、VVC(+)、BV(+)时阴道萎缩发生率(P<0.05)；清洁度Ⅰ/Ⅱ度、菌群密集度+++/++++、菌群多样性+++/++++、pH值3.8~4.5、H2O2 (-)、唾液酸苷酶(-)、BV(-/中介)时阴道萎缩严重程度更低(P<0.05)。清洁度、菌群密集度、菌群多样性、pH值、H2O2、唾液酸苷酶、BV是阴道萎缩病情进展为中/重度独立影响因素(P<0.05)。结论：绝经期女性阴道微生态处于失衡状态，且微生态状况与阴道萎缩发生及发展密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between vaginal microecological status and reproductive tract atrophy in postmenopausal women. Methods: The clinical data of 120 menopausal women in our gynecology clinic of our hospital from 2015 to 2018 were analyzed retrospectively. The cleanliness of all patients' vaginal secretions, the species, density and diversity of dominant bacteria, the vaginal pH, H2O2, leucocyte esterase, sialidase, the positive rate of vulvovaginal candidiasis (VVC), trichomonas vaginitis (TV), bacterial vaginosis (BV), and aerobic vaginosis (AV) were obtained. Then the correlation between vaginal microecology and genital atrophy was analyzed by statistical data. Results: The vaginal cleanness at Ⅲ he vaginal cleanness at nal microecology and genital The predominant bacterial flora was mainly Gram variable coccobacilli, and G- large bacillus, but less G- microbacteria; The density and diversity of flora were high; The proportion of the patients with a pH value of >4.5 was 70%, indicating that the vaginal environment was mostly in neutral/alkaline state. The positive proportion of H2O2, leucocyte esterase, sialidase, VVC and BV was high, while the positive proportion of TV and AV was low. The incidence of vaginal atrophy of cleanliness inal atrophyroportion of TV and AV>4.5 was 70%, indicating that the vaginal environme H2O2 (-), sialidase (-), VVC (-), and BV (-/ intermediate) was lower than that of cleanliness l environmenflora density (not seen/+), flora diversity (not seen/+), pH value > 4.5, H2O2 (+), sialidase (+), VVC (+), and BV (+), with statistic difference (P<0.05). The incidence of vaginal atrophy was the lowest in cleanliness Ⅰ/Ⅱ degree, flora density +++ / ++++, flora diversity +++ / ++++, pH value 3.8~4.5, H2O2 (-), sialidase (-) and BV (-/ intermediate). Cleanliness, flora density, flora diversity, pH value, H2O2, sialidase and BV were the independent influencing factors for the moderate/severe progression of vaginal atrophy (P<0.05). Conclusion: The vaginal microecology of menopausal women is in an unbalanced state, and the microecology is closely related to the occurrence and development of vaginal atrophy. |
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