| 罗利琴,付明亮,高小丹,聂玉涛,廖 东.功能性内窥镜鼻窦术对慢性鼻窦炎患者TIgE、Eos及鼻纤毛传输功能的影响[J].,2020,(18):3461-3465 |
| 功能性内窥镜鼻窦术对慢性鼻窦炎患者TIgE、Eos及鼻纤毛传输功能的影响 |
| Effect of Functional Endoscopic Sinus Surgery on theTige, EOS and Nasal CiliaTransport of Patients with Chronic Sinusitis |
| 投稿时间：2020-04-28 修订日期：2020-05-23 |
| DOI：10.13241/j.cnki.pmb.2020.18.013 |
| 中文关键词: 功能性内窥镜鼻窦术 慢性鼻窦炎 总免疫球蛋白 嗜酸性粒细胞 鼻纤毛传输功能 |
| 英文关键词: Functional endoscopic sinus surgery Chronic sinusitis Total immunoglobulin Eosinophil |
| 基金项目:四川省卫生健康委员会科研项目（19PJ1065） |
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| 中文摘要: |
| 摘要 目的：探讨功能性内窥镜鼻窦术对慢性鼻窦炎患者总免疫球蛋白(TIgE)、嗜酸性粒细胞(Eos)及鼻纤毛传输功能的影响。方法：选择2015年12月-2019年12月在我院接受治疗的120例慢性鼻窦炎患者，采用抽签法将其分为观察组(n=61)和对照组(n=59)。对照组给予传统腺样体刮除术治疗，观察组给予功能性内窥镜鼻窦术治疗。比较两组患者的临床疗效、治疗前后血清TIgE、Eos、白细胞介素4(IL-4)、白细胞介素8(IL-8)、肿瘤坏死因子(TNF-α)水平、鼻黏液纤毛清除率、清除速度、传输速度的变化及并发症的发生情况。结果：治疗后，观察组的总有效率分别为95.08%，明显高于对照组(77.97%，P<0.05)。治疗前，两组血清TIgE、Eos水平比较无明显差异；治疗后，两组血清TIgE、Eos水平均较治疗前显著降低，且观察组血清TIgE、Eos水平均低于对照组(P<0.05)。治疗前，两组鼻黏液纤毛清除率、清除速度、传输速度水平比较均无明显差异；治疗后，两组以上指标均显著升高，且观察组上述指标均高于对照组(P<0.05)。治疗前，两组血清IL-4、IL-8、TNF-α水平无明显差异；治疗后，两组血清IL-4、IL-8、TNF-α水平均较治疗前显著降低，且观察组上述指标均显著低于对照组(P<0.05)。两组并发症总发生率分别为4.92%、20.34%，观察组显著低于对照组(P<0.05)。结论：功能性内窥镜鼻窦术用于慢性鼻窦炎患者的临床效果显著优于传统腺样体刮除术治疗，且安全性更高，其可有效改善患者鼻纤毛传输功能，可能与其降低血清TIgE、Eos水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study The effect of functional endoscopic sinus surgery on Total immunoglobulin (TIgE), eosinophil (Eos) and nasal cilia transport in patients with chronic sinusitis. Methods: 120 patients with chronic sinusitis treated in our hospital from December 2015 to December 2019 were selected and divided into the observation group (n=61) and the control group (n=59) by lottery. The control group was treated with traditional adenoidectomy and the observation group was treated with functional endoscopic sinus surgery. The clinical efficacy, serum TIgE, Eos, interleukin-4 (IL-4), interleukin-8 (IL-8), tumor necrosis factor (TNF-?琢) levels, nasal mucociliary clearance rate, clearance rate, transmission rate and complications were compared between the two groups before and after treatment. Results: After treatment, the total effective rate of observation group was 95.08%, which was significantly higher than that of the control group (77.97%, P<0.05). Before treatment, there was no significant difference in the serum TIgE and Eos levels between the two groups. After treatment, the serum TIgE and Eos levels in both groups were significantly lower than those before treatment, which were lower than those in the control group (P<0.05). Before treatment, there was no significant difference in clearance rate, clearance speed and transmission speed between the two groups. After treatment, the above indexes in both groups were significantly increased, and those in the observation group were higher than those in the control group (P<0.05). Before treatment, there was no significant difference in the serum IL-4, IL-8 and TNF-α levels between the two groups. After treatment, the serum IL-4, IL-8 and TNF-α levels in both groups were significantly lower than those before treatment, and the above indicators in the observation group were significantly lower than those in the control group (P<0.05). The total incidence of complications in the two groups was 4.92% and 20.34%, respectively, which was significantly lower in the observation group than that of the control group (P<0.05). Conclusion: The clinical effect of functional endoscopic sinus surgery in patients with chronic sinusitis is significantly better than that of traditional adenoid curettage with higher safety. It can effectively improve the nasal ciliary transport function in patients, which may be related to the reduction of serum TIgE and Eos levels. |
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