| 李 雯,赵伟伟,葛建敏,吴俊峰,董建芳,石 蔚,石 花.百蕊颗粒联合阿奇霉素及布地奈德雾化吸入治疗对咳嗽变异性哮喘患儿肺功能和炎症因子的影响[J].,2020,(16):3156-3159 |
| 百蕊颗粒联合阿奇霉素及布地奈德雾化吸入治疗对咳嗽变异性哮喘患儿肺功能和炎症因子的影响 |
| Effect of Baili Granule Combined with Azithromycin and Budesonide on Pulmonary Function and Inflammatory Factors in Children with Cough Variant Asthma |
| 投稿时间：2020-02-18 修订日期：2020-03-13 |
| DOI：10.13241/j.cnki.pmb.2020.16.034 |
| 中文关键词: 百蕊颗粒 阿奇霉素 布地奈德 咳嗽变异性哮喘 患儿 肺功能 炎症因子 |
| 英文关键词: Baisui granule Azithromycin Budesonide Cough variant asthma Children Lung function Inflammatory factors |
| 基金项目:河北省医学科学研究重点项目（20150139）；张家口市级科技计划自筹经费项目（1921082D） |
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| 中文摘要: |
| 摘要 目的：探讨百蕊颗粒联合阿奇霉素及布地奈德雾化吸入治疗对咳嗽变异性哮喘（CVA）患儿肺功能和炎症因子的影响。方法：选取我院于2017年2月~2019年10月期间接收的CVA患儿97例，根据随机数字表法将患儿分为研究组（n=49）和对照组（n=48），对照组患儿予以阿奇霉素及布地奈德雾化吸入治疗，研究组在对照组的基础上联合百蕊颗粒治疗，记录两组患儿临床疗效、临床指标及不良反应发生情况，检测两组患儿炎症因子[白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）]水平及第1秒用力呼气容积（FEV1）、用力肺活量（FVC），计算FEV1/FVC。结果：研究组治疗8周后的临床总有效率为91.84%（45/49），高于对照组的75.00%（36/48）（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。两组治疗8周后FEV1/FVC、FVC、FEV1均较治疗前升高，且研究组高于对照组（P<0.05）。两组治疗8周后IL-6、TNF-α、PCT均下降，且研究组低于对照组（P<0.05）。研究组咳嗽缓解时间、咳嗽消失时间均短于对照组（P<0.05）。结论：百蕊颗粒联合阿奇霉素及布地奈德雾化吸入治疗CVA患儿疗效确切，可有效改善患儿肺功能及临床指标，降低炎症因子水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Baili granule combined with azithromycin and budesonide on pulmonary function and inflammatory factors in children with cough variant asthma (CVA). Methods: 97 children with CVA who were treated in our hospital from February 2017 to October 2019 were selected, they were randomly divided into study group (n=49) and control group (n=48) according to the random number table method. Children in the control group were treated with azithromycin and budesonide atomization inhalation. The study group was treated with Baili granule on the basis of the control group, the curative effect, clinical indexes and adverse reactions of the two groups were recorded, the levels of inflammatory factors [Interleukin-6 (IL-6), tumor necrosis factor -α (TNF-α), procalcitonin (PCT)] and forced vital capacity (FVC) in the first second were measured and FEV1/FVC were calculated. Results: The total clinical effective rate of the study group was 91.84% (45/49), which was higher than 75.00% (36/48) of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). FEV1/FVC, FVC and FEV1 in the two groups increased 8 weeks after treatment, and the study group were higher than those in the control group (P<0.05). The levels of IL-6, TNF –α and PCT in the study group were lower than those in the control group (P<0.05). The cough relief time and cough disappearance time in the study group were shorter than those in the control group (P<0.05). Conclusion: Baili granule combined with azithromycin and budesonide atomization inhalation is effective in the treatment of children with CVA, which can effectively improve the lung function and clinical indicators, and reduce the level of inflammatory factors. |
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