| 周 宇,陈 新,陈旭兵,柳兆刚,唐振华,王娜娜,刘效文.改良型腮腺切除术治疗腮腺肿瘤的效果观察及对血清CA125、β2-MG水平的影响[J].,2020,(15):2987-2990 |
| 改良型腮腺切除术治疗腮腺肿瘤的效果观察及对血清CA125、β2-MG水平的影响 |
| Efficacy of Modified Parotid Gland Resection in the Treatment of Parotid Gland Tumor and Its Effects on the Serum CA125 and β2-MG Levels |
| 投稿时间：2020-02-26 修订日期：2020-03-22 |
| DOI：10.13241/j.cnki.pmb.2020.15.039 |
| 中文关键词: 改良型腮腺切除术 腮腺肿瘤 糖链抗原125 β2微球蛋白 |
| 英文关键词: Modified parotidectomy Parotid gland neoplasm Carbohydrate antigen 125 β2 microglobulin |
| 基金项目:安徽省自然科学基金项目(104066M204) |
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| 中文摘要: |
| 摘要 目的：分析改良型腮腺切除术治疗腮腺肿瘤的效果及对血清糖链抗原125(CA125)、β2微球蛋白(β2-MG)水平的影响。方法：选择2016年12月-2019年12月我院收治的腮腺肿瘤患者80例纳入本次研究，采用随机数表法分为观察组(n=41)和对照组(n=39)。对照组使用传统腮腺切除术进行治疗，观察组采用改良型腮腺切除术进行治疗。比较两组患者手术情况、手术前后血清CA125、β2-MG、生活质量评分的变化及面部神经损伤和并发症的发生情况。结果：两组手术时间、术中出血量及术后当日引流量比较均无显著差异；观察组住院时间、手术切口长度均显著低于对照组(P<0.05)；治疗后，两组血清CA125、β2-MG水平均较治疗前显著下降，且观察组低于对照组(P<0.05)；观察组面部神经总损伤率为12.20%，显著低于对照组(35.90%，P<0.05)。治疗后，两组生活质量评分均较治疗前显著升高，且观察组显著高于对照组(P<0.05)；两组并发症总发生率分别为9.76%、28.21%，差异显著(P<0.05)。结论：采用改良型腮腺切除术治疗腮腺肿瘤患者的临床效果显著，且安全性高，并可有效改善患者生活质量，降低CA125、β2-MG水平。 |
| 英文摘要: |
| ABSTRACT Objective: To study the efficacy of modified parotid gland resection in the treatment of parotid gland tumor and its effect on the serum Glycemic chain antigen 125 (CA125), β2-MG(lob2-mg) levels. Methods: 80 cases of parotid gland tumor patients admitted to our hospital from December 2016 to December 2019 were included in this study, and were randomly divided into the observation group (n=41) and the control group (n=39). The control group was treated with traditional parotidectomy, while the observation group was treated with modified parotidectomy. The operation status, changes of serum CA125, livelihood quality score before and after operation, and incidence of facial nerve injury and complications were compared between two groups. Results: There was no significant difference between the two groups in operation time, intraoperative blood loss and postoperative daily drainage volume. The length of hospital stay and incision length in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the serum levels of CA125 and 2-mg in both groups were significantly lower than that before treatment, and the observation group was lower than the control group (P<0.05). The total facial nerve injury rate in the observation group was 12.20%, significantly lower than that in the control group (35.90%, P<0.05). After treatment, the quality of life scores of both groups were significantly higher than before treatment, and the observation group was significantly higher than the control group (P<0.05). The total incidence of complications in the two groups was 9.76% and 28.21%, respectively, with significant differences (P<0.05). Conclusion: Modified parotid gland resection for parotid gland tumor patients has significant clinical effect with high safety, and can effectively improve the quality of life, as well as reduce the level of CA125, β2-MG. |
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