| 刘朝曦,王 凯,吴丽娜.多核磁共振19F-MRI在分子影像学中的应用[J].,2020,(14):2795-2800 |
| 多核磁共振19F-MRI在分子影像学中的应用 |
| Applications of Multinuclear Magnetic Resonance 19F-MRI in Molecular Imaging |
| 投稿时间：2019-12-06 修订日期：2019-12-30 |
| DOI：10.13241/j.cnki.pmb.2020.14.043 |
| 中文关键词: 19F-MRI PFC 分子成像 细胞示踪 氧分压测定 |
| 英文关键词: 19F-MRI PFC Molecular imaging Cell tracing Partial oxygen pressure measurement |
| 基金项目:国家自然科学基金项目（81771903；81627901）；国家重大科学研究计划项目纳米专项（2015CB931800） |
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| 中文摘要: |
| 摘要：随着杂核氟、钠、磷等探针和成像技术的发展以及磁共振成像设备和序列的优化，多核磁共振迅速崛起，尤其是其在分子影像方面的研究与应用使包括心血管、肿瘤等众多疾病从传统的形态学影像诊断模式转向早期分子影像精准诊治模式。其中，19F-MRI多核磁共振分子成像近年来备受瞩目。虽然19F-MRI的成像敏感度是1H-MRI的82%，但人体只有牙齿中含有少量的氟，因此无背底噪声的干扰。19F-MRI应用氟类探针，19F自然丰度100%，且无放射性。本文简述了多核磁共振在分子影像学中的应用，并重点介绍19F-MRI分子影像及其应用探针在精准诊治方面的应用。 |
| 英文摘要: |
| ABSTRACT: With the development of imaging probes and technologies such as heteronuclear fluorine, sodium and phosphorus, and the optimization of magnetic resonance imaging equipment and sequences, multi-nuclear magnetic resonance has rapidly emerged. Especially, its research and application in molecular imaging has made the diagnosis of many diseases such as cardiovascular disease, tumors,et al shift from traditional diagnostic patterns with morphological imaging to early precise diagnosis and treatment patterns with molecular imaging. Among them, multi-nuclear magnetic resonance molecular imaging 19F-MRI has attracted much attention in recent years. Although the imaging sensitivity of 19F-MRI is 82% of 1H-MRI, the human body only contains a small amount of fluorine in the teeth, so there is no interference from the background noise. The 19F-MRI applies fluorine-based probes. 19F has a natural abundance of 100% and is non-radioactive. This article briefly describes the application of multi-nuclear magnetic resonance in molecular imaging, and focuses on the application of 19F-MRI molecular imaging and related probes in the field of precise diagnosis and treatment. |
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