| 赵 琪,关炳星,马 骏,付素珍,李 辉.乌司他丁联合生长抑素辅助连续血液净化对重症胰腺炎患者血清HSP70、IL-15、HMGB1水平的影响[J].,2020,(14):2745-2749 |
| 乌司他丁联合生长抑素辅助连续血液净化对重症胰腺炎患者血清HSP70、IL-15、HMGB1水平的影响 |
| Effects of Ulinastatin Combined with Somatostatin Assisted Continuous Blood Purification on the Serum HSP70, IL-15, HMGB1 Levels in Patients with Severe Pancreatitis |
| 投稿时间：2020-02-27 修订日期：2020-03-22 |
| DOI：10.13241/j.cnki.pmb.2020.14.032 |
| 中文关键词: 重症胰腺炎 连续血液净化 乌司他丁 生长抑素 热休克蛋白70 白介素-15 高迁移率族蛋白B1 |
| 英文关键词: Severe Pancreatitis Continuous blood purification Ulinastatin Somatostatin Heat shock protein 70 Interleukin-15 high mobility group protein |
| 基金项目:河北省卫生健康委员会项目（20200867） |
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| 摘要 目的：研究乌司他丁联合生长抑素辅助连续血液净化对重症胰腺炎患者血清热休克蛋白70(Heat shock protein 70，HSP70)、白介素-15(Interleukin-15，IL-15)、高迁移率族蛋白B1(high mobility group protein1，HMGB1)水平的影响。方法：选择2018年5月~2019年10月在我院就诊的82例重症胰腺炎患者，依据入院先后顺序分为对照组(40例)和研究组(42例)。对照组采用生长抑素辅助连续血液净化治疗，研究组采用乌司他丁联合生长抑素辅助连续血液净化治疗。观察和比较两组临床疗效，症状改善时间，治疗前后血清白蛋白(albumin，Alb)、尿素氮(Urea nitrogen，BUN)、血肌酐(Serum creatinine，Scr)、血淀粉酶(amylase，AMY)、HSP70、IL-15、HMGB1水平及急性生理学及慢性健康状况(APACHEⅡ)评分的变化情况和不良反应的发生情况。结果：治疗后，研究组总有效率显著高于对照组(P<0.05)，症状改善时间及住院时间均少于对照组(P<0.05)。治疗后，两组Alb均较治疗前显著上升，BUN、Scr、AMY、APACHEⅡ评分、血清HSP70、IL-15、HMGB1水平均较治疗前明显下降，研究组以上指标的变化较对照组更明显(P<0.05)。两组不良反应总发生率比较无统计学差异(P>0.05)。结论：乌司他丁联合生长抑素辅助血液净化有利于重症胰腺炎患者病情恢复，减轻临床症状，降低HSP70、IL-15和HMGB1水平。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of ulinastatin combined with somatostatin on serum 70(Heat shock protein 70 (HSP70), interleukin-15 (IL-15) and B1(high mobility group protein1 B1 (HMGB1) levels in patients with severe pancreatitis. Methods: 82 patients with severe pancreatitis admitted to our hospital from may 2018 to October 2019 were selected and divided into control group (40 cases) and research group (42 cases) according to the admission order. The control group was treated with somatostatin assisted continuous blood purification, while the research group was treated with ulinastatin combined with somatostatin assisted continuous blood purification. The clinical efficacy, improvement time of symptoms, changes of serum albumin (ALB), Urea nitrogen (BUN), Serum creatinine (Scr), serum amylase (AMY), HSP70, IL-15, HMGB1, acute physiology and chronic health status (APACHEⅡ II) scores and occurrence of adverse reactions were observed and compared between the two groups before and after treatment. Results: After treatment, the total effective rate of the research group was significantly higher than that of the control group (P<0.05), and the time of symptom improvement and hospitalization were lesser than that of the control group (P<0.05). After treatment, Alb in both groups increased significantly compared with that before treatment. BUN, Scr, AMY, APACHEⅡ scores, serum HSP70, IL-15, HMGB1 levels were significantly decreased compared with that before treatment. the changes of above indexes in the research group were more obvious than those in the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion: Ulinastatin combined with somatostatin assisted blood purification is beneficial to the recovery of patients with severe pancreatitis, alleviating clinical symptoms and reducing the levels of HSP70, IL-15 and HMGB1. |
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