| 余 蓉,梁美婷,曹 正,严晓伟,王建荣.肺炎支原体肺炎伴喘息儿童血清25(OH)D_3、Th17/Treg表达水平与肺功能的关系[J].,2020,(14):2723-2727 |
| 肺炎支原体肺炎伴喘息儿童血清25(OH)D_3、Th17/Treg表达水平与肺功能的关系 |
| The Relationship between the Expression of Serum 25(OH)D_3, Th17/Treg and Pulmonary Function in Children with Mycoplasma Pneumonia and Wheezing |
| 投稿时间：2019-12-27 修订日期：2020-01-23 |
| DOI：10.13241/j.cnki.pmb.2020.14.027 |
| 中文关键词: 肺炎支原体肺炎 儿童 喘息 25羟基维生素D3 Th17/Treg |
| 英文关键词: Mycoplasma pneumoniae pneumonia Children Wheezing 25(OH)D_3 Th17/Treg |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2016D02C1054） |
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| 中文摘要: |
| 摘要 目的：探讨肺炎支原体肺炎伴喘息儿童血清25羟基维生素D3[25(OH)D_3]、辅助性17细胞/调节性T细胞（Th17/Treg）表达水平与肺功能的关系。方法：将新疆医科大学第五附属医院收治的肺炎支原体肺炎伴喘息患儿26例作为肺炎伴喘息组，肺炎支原体肺炎不伴有喘息患儿54例作为肺炎不伴喘息组，另选取健康儿童30例作为对照组，比较各组血清25(OH)D_3、白细胞介素（IL）-10、IL-17、Th17细胞及Treg细胞占CD4+T细胞比例及肺功能，并分析其相关性。结果：肺炎伴喘息组血清25(OH)D_3、IL-10、Treg细胞占CD4+T细胞比例低于肺炎不伴喘息组、对照组，Th17细胞占CD4+T细胞比例、Th17/Treg、IL-17高于肺炎不伴喘息组、对照组（P<0.05）。各组第一秒最大呼气量占用力肺活量百分比（FEV1/FVC）比较差异无统计学意义（P>0.05），肺炎伴喘息组FEV1占预计值百分比（FEV1%pred）、峰值呼气流量（PEF）低于肺炎不伴喘息组、对照组（P<0.05），肺炎不伴喘息组与对照组FEV1%pred、PEF比较无统计学意义（P>0.05）。肺炎伴喘息组患儿血清25(OH)D_3与Th17/Treg、IL-17呈负相关（P<0.05），与IL-10、FEV1%pred、PEF呈正相关（P<0.05），血清Th17/Treg与IL-10、FEV1%pred、PEF呈负相关（P<0.05），与IL-17呈正相关（P<0.05）。结论：肺炎支原体肺炎伴喘息儿童血清25(OH)D_3、Th17/Treg表达水平异常，肺功能下降，且25(OH)D_3、Th17/Treg表达水平与肺功能相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of serum 25 (OH) D_3, T help 17/Regulatory T (Th17/Treg) and pulmonary function in children with mycoplasma pneumonia and wheezing. Methods: 26 children with Mycoplasma pneumoniae pneumonia and wheezing in the Fifth Affiliated Hospital of Xinjiang Medical University were treated as pneumonia with wheezing group, 54 children with mycoplasma pneumonia without wheezing were treated as pneumonia without wheezing group, and 30 healthy children were selected as control group. Serum 25 (OH) D_3, interleukin (IL)-10, IL-17, proportion of Th17 cells and Treg cells in CD4+T cells and lung function of each group were compared, and their correlation were analyzed. Results: Serum 25 (OH) D_3, IL-10 and proportion of Treg cells in CD4+T cells in pneumonia with wheezing group were lower than those in pneumonia without wheezing group and control group. proportion of Th17 cells in CD4+T cells, Th17/Treg and IL-17 were higher than those in pneumonia without wheezing group and control group (P<0.05). There was no significant difference in Percentage of maximal expiratory volume occupied by vital capacity in the first second(FEV1/FVC) among groups (P>0.05). FEV1 Percentage of Predicted Value(FEV1%pred) and peak expiratory flow (PEF) in pneumonia with wheezing group were lower than those in pneumonia without wheezing group and control group (P<0.05). There were no significant differences in FEV1%pred and PEF between pneumonia without wheezing group and control group (P>0.05). Serum 25(OH)D_3 was negatively correlated with Th17/Treg and IL-17(P<0.05), positively correlated with IL-10 (P<0.05), FEV1%pred and PEF (P<0.05). Serum Th17/Treg negatively correlated with IL-10, FEV1%pred and PEF (P<0.05), and positively correlated with IL-17 (P<0.05). Conclusion: The expression levels of serum 25(OH)D_3 and Th17/Treg in children with mycoplasma pneumonia and wheezing are abnormal, the pulmonary function is decreased, and the expression levels of 25(OH)D_3, Th17/Treg are correlated with pulmonary function. |
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