文章摘要
陈永禄,温丽慧,刘海媚,周 丹,谢友琴.中医序贯疗法联合丙酸氟替卡松鼻喷雾剂治疗慢性鼻窦炎的疗效评估[J].,2020,(12):2367-2370
中医序贯疗法联合丙酸氟替卡松鼻喷雾剂治疗慢性鼻窦炎的疗效评估
Curative Efficacy of Sequential Therapy of Traditional Chinese Medicine Combined with Fluticasone Propionate Nasal Sprayinthe Treatment of Chronic Sinusitis
投稿时间:2020-01-28  修订日期:2020-02-23
DOI:10.13241/j.cnki.pmb.2020.12.037
中文关键词: 中医序贯疗法  丙酸氟替卡松鼻喷雾剂  慢性鼻窦炎  鼻黏膜纤毛传输速率  炎性因子
英文关键词: Sequential therapy of Chinese medicine  Fluticasone propionate nasal spray  Chronic sinusitis  Transmission rate of nasal mucosa cilia  Inflammatory cytokines
基金项目:北京市自然科学基金项目(7102030)
作者单位E-mail
陈永禄 北京中医药大学深圳医院耳鼻咽喉科 北京 518172 liuxuelu307@163.com 
温丽慧 广西钦州市第二人民医院耳鼻咽喉科 广西 钦州 535000  
刘海媚 北京中医药大学深圳医院耳鼻咽喉科 北京 518172  
周 丹 北京中医药大学深圳医院耳鼻咽喉科 北京 518172  
谢友琴 北京中医药大学深圳医院耳鼻咽喉科 北京 518172  
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中文摘要:
      摘要 目的:探讨中医序贯疗法联合丙酸氟替卡松鼻喷雾剂治疗慢性鼻窦炎的临床疗效。方法:选择2017年8月至2019年2月在我院接受治疗的120例慢性鼻窦炎Ⅱ型患者,采用抽签法分为观察组(n=61)和对照组(n=59)。两组均给予功能性内镜鼻窦手术治疗,对照组给予丙酸氟替卡松鼻喷雾剂治疗,观察组在对照组的基础上给予中医序贯疗法治疗。比较两组患者的临床疗效,治疗前后鼻黏膜纤毛传输速率(MTR)、血清白细胞介素4(IL-4)、白细胞介素6(IL-6)、肿瘤坏死因子(TNF-α)、中医症候积分水平的变化情况及并发症的发生情况。结果:治疗后,两组总有效率分别为96.72%,79.66%,观察组显著高于对照组(P<0.05);两组MTR、血清IL-4、IL-8、TNF-α水平均较治疗前显著改善,且观察组MTR高于对照组,血清IL-4、IL-8、TNF-α水平明显低于对照组(P<0.05);两组中医症候积分水平均较治疗前显著降低,且观察组中医症候积分水平显著低于对照组(P<0.05)。治疗期间,两组并发症总发生率分别为1.64%、15.25%观察组显著低于对照组(P<0.05)。结论:中医序贯疗法联合丙酸氟替卡松鼻喷雾剂慢性鼻窦炎患者的临床效果显著优于丙酸氟替卡松鼻喷雾剂治疗,其可更有效改善患者MTR。减轻炎症反应,且安全性更高。
英文摘要:
      ABSTRACT Objective: To study the curative efficacy of sequential therapy of traditional Chinese medicine combined with fluticasone propionate nasal sprayin in the treatment of Chronic sinusitisand its effects on the Nasal mucosa ciliary transmission rate (MTR) and inflammatory factors. Methods: 120 patients with type II chronic sinusitis treated in our hospital from August 2017 to February 2019 were selected and divided into the observation group (n=61) and the control group (n=59) by lottery. Both groups were treated with functional endoscopic sinus surgery, the control group was treated with fluticasone propionate nasal spray, and the observation group was treated with sequential therapy of traditional Chinese medicine on the basis of control group. The clinical efficacy, changes in nasal mucosa ciliary transport rate (MTR), serum interleukin 4(il-4), interleukin 6(il-6), tumor necrosis factor-α(TNF-α), and score of TCM symptoms and incidence of complications before and after treatment were compared between two groups. Results: After treatment, the total effective rates of the two groups were 96.72% and 79.66%, respectively, which were significantly higher in the observation group than that in the control group (P<0.05). The levels of MTR, serum IL-4, IL-8 and TNF-α in both groups were significantly improved compared with those before treatment, and the levels of serum IL-4, IL-8 and TNF-α in the observation group were significantly lower than those in the control group (P<0.05). The score level of TCM symptoms in both groups was significantly lower than that before treatment, and the score level of TCM symptoms in the observation group was significantly lower than that in the control group (P<0.05). During the treatment period, the total incidence of complications in the two groups was 1.64% and 15.25%, respectively, which was significantly lower in the observation group than that of the control group (P<0.05). Conclusion: The clinical effect of sequential therapy combined with fluticasone propionate nasal spray in the treatment of patients with chronic sinusitis is significantly better than that of fluticasone propionate nasal spray, which can more effectively improve the MTR and reduce inflammation with higher safety.
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