文章摘要
孙 燕,曹 丽,董倩兰,王 琼,高瑞瑞.血液透析、灌流对糖尿病肾病患者血清TNF-α、CRP、IL-6水平的影响[J].,2020,(12):2325-2328
血液透析、灌流对糖尿病肾病患者血清TNF-α、CRP、IL-6水平的影响
Effect of Hemodialysis and Perfusion on the Serum TNF-α, CRP and IL-6 Levels in the Patients with Diabetic Nephropathy
投稿时间:2019-09-29  修订日期:2019-10-24
DOI:10.13241/j.cnki.pmb.2020.12.027
中文关键词: 血液透析  血液灌流  糖尿病肾病  TNF-α  CRP  IL-6
英文关键词: Hemodialysis  Blood perfusion  Diabetic nephropathy  TNF-α  CRP  IL-6
基金项目:陕西省重点研发项目:一般项目-社会发展领域 (2018SF-168)
作者单位E-mail
孙 燕 陕西省人民医院肾病血透中心 陕西 西安 710068 yanzi7591@163.com 
曹 丽 榆林市第二医院肾病内科 陕西 榆林 719000  
董倩兰 陕西省人民医院肾病血透中心 陕西 西安 710068  
王 琼 陕西省人民医院肾病血透中心 陕西 西安 710068  
高瑞瑞 榆林市第二医院肾病内科 陕西 榆林 719000  
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中文摘要:
      摘要 目的:探讨血液透析辅助血液灌流对终末期糖尿病肾病血清C反应蛋白(C-reactive protein, CRP)、肿瘤坏死因子(tumor necrosis factor, TNF-α)及白细胞介素(Interleukin,IL)-6水平的影响。方法:选取近3年收治的79例糖尿病肾病患者,将其随机分为研究组(n=40)和对照组(n=39),对照组患者接受血液透析治疗,研究组患者接受血液透析辅助血液灌流治疗,对比两组患者治疗前后血清TNF-α、CRP、IL-6水平的变化情况。结果:治疗后,研究组患者的治疗总有效率、血红蛋白(haemoglobin,Hb)、转铁蛋白水平(transferring,TRF)、白蛋白(albumin,Alb)及营养不良-炎症评分(malnutrition inflammation score,MIS)均明显高于对照组(P<0.05),而MIS评分明显低于对照组(P<0.05);两组患者治疗后血清CRP、TNF-α、IL-6水平均明显低于治疗前(P<0.05),且研究组患者以上指标明显低于对照组(P<0.05)。结论:血液透析辅助血液灌流治疗糖尿病肾病可显著改善患者的临床症状和营养状态,降低TNF-α、CRP、IL-6水平,减轻炎症反应。
英文摘要:
      ABSTRACT Objective: To investigate the effect of hemodialysis assisted hemoperfusion on serum TNF-α, CRP, IL-6 levels in end-stage diabetic nephropathy. Methods: 79 patients with diabetic nephropathy admitted in the past 3 years were randomly divided into the study group (n=40) and the control group (n=39). The control group received hemodialysis treatment. The study group received hemodialysis assistance blood perfusion. Treatment, comparing the changes of serum TNF-α, CRP and IL-6 levels before and after treatment in the two groups. Results: After treatment, the total effective rate of treatment, hemoglobin (Hb), transferrin (TRF), albumin (Alb), and malnutrition inflammation score (MIS) were all in the study group. The MIS score was significantly lower than that of the control group (P<0.05). The levels of serum CRP, TNF-α and IL-6 in the two groups were significantly lower than those before treatment (P<0.05), and the above indicators of the study group were significantly lower than the control group (P<0.05). Conclusion: Hemodialysis-assisted blood perfusion for the treatment of diabetic nephropathy can significantly improve the clinical symptoms and nutritional status of patients, reduce TNF-α, CRP, IL-6 levels, reduce inflammation.
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