文章摘要
唐幸一,李一奇,孙宣东,李伟忠,肖 栋.玉屏风散联合头孢丙烯对鼻炎患者免疫功能及应激损伤程度的影响[J].,2020,(12):2313-2316
玉屏风散联合头孢丙烯对鼻炎患者免疫功能及应激损伤程度的影响
Effect of Yupingfeng San Combined with Cefalexin on the Immune Function and Stress Injury in Patients with Rhinitis
投稿时间:2019-10-23  修订日期:2019-11-19
DOI:10.13241/j.cnki.pmb.2020.12.024
中文关键词: 玉屏风散  鼻炎  免疫功能  氧化应激  炎症损伤
英文关键词: Yupingfeng San  Rhinitis  Immune Function  Oxidative Stress  Inflammatory Injury
基金项目:江苏省人力和社会保障厅"六大人才高峰"计划项目(2014-WSW-060)
作者单位E-mail
唐幸一 无锡市江南大学附属医院(无锡三院)耳鼻咽喉科 江苏 无锡 214000 txy8763@163.com 
李一奇 无锡市江南大学附属医院(无锡三院)耳鼻咽喉科 江苏 无锡 214000  
孙宣东 无锡市江南大学附属医院(无锡三院)耳鼻咽喉科 江苏 无锡 214000  
李伟忠 无锡市江南大学附属医院(无锡三院)耳鼻咽喉科 江苏 无锡 214000  
肖 栋 无锡市江南大学附属医院(无锡三院)耳鼻咽喉科 江苏 无锡 214000  
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中文摘要:
      摘要 目的:探讨玉屏风散联合头孢丙烯对鼻炎患者免疫系统及应激损伤程度的影响。方法:将2016年8月~2018年2月我院收治的鼻炎患者120例按照随机数字表法分为对照组与观察组,每组60例。对照组患者给予头孢丙烯治疗;观察组患者给予玉屏风散联合头孢丙烯治疗。两组患者均连续治疗14天。分别于治疗前后检测并比较两组患者血清环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)、免疫球蛋白E(Ig E)、辅助T细胞1/辅助T细胞2(Th1/Th2)、一氧化氮(NO)、丙二醛(MDA)、超氧化物歧化酶(SOD)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及γ-干扰素(IFN-γ)水平的变化。结果:治疗后:两组患者血清cAMP、Th1/Th2比值及SOD水平较治疗前显著升高;cGMP、IgE、NO、MDA、CRP、TNF-α及IFN-γ水平较治疗前显著降低(P<0.05),且观察组患者血清cAMP、Th1/Th2比值及SOD水平明显高于对照组,cGMP、IgE、NO、MDA、CRP、TNF-α及IFN-γ水平明显低于对照组(P<0.05)。结论:玉屏风散联合头孢丙烯治疗鼻炎患者可提高患者免疫功能,同时减轻氧化应激及炎症反应损伤。
英文摘要:
      ABSTRACT Objective: To investigate the effect of Yupingfeng San combined with Cefalexin on immune system and stress injury in patients with rhinitis. Methods: 120 patients with rhinitis admitted to our hospital from August 2016 to February 2018 were randomly divided into control group and observation group, 60 cases in each group. The patients in the control group were treated with cefalexin, while those in the observation group were treated with Yupingfeng San and cefalexin. Patients in both groups were treated continuously for 14 days. The serum levels of Cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), immunoglobulin E (Ig E), helper T cell 1/helper T cell 2(Th1/Th2), nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in serum of the the paients in the two groups were detected and compared before and after treatment. Results: After treatment, the serum levels of cAMP, Th1/Th2 ratio and SOD of patients in the control group were significantly higher than those before treatment, while the levels of cGMP, IgE, NO, MDA, CRP, TNF-α and IFN-γ were significantly lower than those before treatment (P<0.05). After treatment, the changes of serum levels of these factors in the observation group were the same as those in the control group. The serum levels of cAMP, Th1/Th2 ratio and SOD of patients in the observation group were significantly higher than those in the control group, and the levels of cGMP, IgE, NO, MDA, CRP, TNF-α and IFN-γ of patients in the observation group were significantly lower than those in the control group (P<0.05). Conclusion: Yupingfeng San combined with Cefalexin has significant clinical effect in the treatment of rhinitis. Yupingfeng San can improve the immune function of patients by regulating the levels of cytokines, and at the same time reduce oxidative stress and inflammatory reaction damage.
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