文章摘要
梁妍琰,白玉新,张国栋,冯万禹,朱 华.血清BNP、h-FABP对川崎病患儿的诊断价值分析[J].,2020,(12):2305-2308
血清BNP、h-FABP对川崎病患儿的诊断价值分析
Diagnostic Values of Serum BNP and h-FABP in Children with Kawereaki Disease
投稿时间:2019-10-10  修订日期:2019-10-31
DOI:10.13241/j.cnki.pmb.2020.12.022
中文关键词: 脑钠肽  心肌型脂肪酸结合蛋白  川崎病  相关性  诊断价值
英文关键词: Brain natriuretic peptide  Myocardial fatty acid binding protein  Kawereaki disease  Correlation  Diagnostic value
基金项目:内蒙古自治区科技计划项目(201602098)
作者单位E-mail
梁妍琰 内蒙古自治区人民医院儿科 内蒙古 呼和浩特 010017 liangyanyan_789@163.com 
白玉新 内蒙古自治区人民医院儿科 内蒙古 呼和浩特 010017  
张国栋 内蒙古自治区人民医院儿科 内蒙古 呼和浩特 010017  
冯万禹 内蒙古自治区人民医院儿科 内蒙古 呼和浩特 010017  
朱 华 内蒙古自治区人民医院儿科 内蒙古 呼和浩特 010017  
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中文摘要:
      摘要 目的:探讨与分析血清脑钠肽(Brain natriuretic peptide,BNP)、心肌型脂肪酸结合蛋白(heart type fatty acid binding protein,H-FABP)对川崎病(Kawasaki disease,KD)患儿的诊断价值。方法:采用病例对照的方法,选择2018年1月至2019年7月在本院诊治住院的川崎病患儿78例作为川崎病组,选取同期体检的健康儿童78例作为对照组。调查两组的临床资料,检测血清BNP、h-FABP水平并进行诊断价值判断。结果:两组的一般资料无统计学意义(P>0.05)。川崎病组的白细胞计数、血小板计数、淋巴细胞计数显著高于对照组,红细胞比容与血红蛋白值显著低于对照组(P<0.05)。川崎病组患儿的血清BNP、h-FABP含量都显著高于对照组(P<0.05)。在川崎病组中,Spearman等级相关性分析显示BNP与h-FABP呈显著正相关性(r=0.782,P=0.000)。受试者工作特征曲线(receiver operating characteristic curve,ROC)显示BNP与h-FABP诊断川崎病的曲线下面积分别为0.822、0.845,诊断灵敏性、特异性与准确性都在70.0 %以上。结论:血清BNP、h-FABP在川崎病患儿中呈现高表达状况,对川崎病也有很好的诊断价值,可为临床诊治起到一定的指导作用。
英文摘要:
      ABSTRACT Objective: To investigate and analysis the diagnostic values of brain natriuretic peptide (BNP) and heart type fatty acid binding protein (H-FABP) in children with Kawereaki disease (KD). Methods: Used a case-control method,78 children with Kawasaki disease who were hospitalized in our hospital from January 2018 to July 2019 were selected as Kawasaki disease group, and 78 healthy children with concurrent physical examination were selected as the control group. Investigate the clinical data of the two groups, detect serum BNP, h-FABP levels and make diagnostic value judgment. Results: The general data of the two groups were not statistically significant (P>0.05). The white blood cell count, platelet count and lymphocyte count of Kawasaki disease group were significantly higher than those of the control group, and the hematocrit and hemoglobin values were significantly lower than the control group (P<0.05). The serum BNP and h-FABP levels in the Kawereaki disease group were significantly higher than in the control group (P<0.05). In the Kawereaki disease group, Spearman rank correlation analysis showed there were significant positive correlation between BNP and h-FABP (r=0.782, P=0.000). The receiver operating characteristic curve (ROC) showed that the area under the curve of BNP and h-FABP for the diagnosis of Kawereaki disease were 0.822 and 0.845, respectively, and the diagnostic sensitivity, specificity and accuracy were above 70.0%. Conclusion: Serum BNP and h-FABP are highly expressed in children with Kawereaki disease, and have good diagnostic values for Kawereaki disease, which can play guiding roles in clinical diagnosis and treatment.
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