| 李世勇,陈远洋,韦启志,冯桂贞,林安基.化痰通络汤联合常规西医治疗对缺血性卒中患者神经功能、血小板功能及血清炎性因子的影响[J].,2020,(12):2293-2296 |
| 化痰通络汤联合常规西医治疗对缺血性卒中患者神经功能、血小板功能及血清炎性因子的影响 |
| Effects of Huatan Tongluo Decoction Combined with Routine Western Medicine on Neurological Function, Platelet Function and Serum Inflammatory Factors in Patients with Ischemic Stroke |
| 投稿时间：2019-11-29 修订日期：2019-12-25 |
| DOI：10.13241/j.cnki.pmb.2020.12.019 |
| 中文关键词: 化痰通络汤 常规西医 缺血性卒中 神经功能 血小板功能 |
| 英文关键词: Huatan Tongluo decoction Routine western medicine Ischemic stroke Neurological function Platelet function |
| 基金项目:福建省卫生厅中医药项目(wzpw201308) |
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| 中文摘要: |
| 摘要 目的：探讨化痰通络汤联合常规西医治疗对缺血性卒中患者神经功能、血小板功能及血清炎性因子的影响。方法：选取我院于2016年2月~2019年2月接收的缺血性卒中患者101例，按照乱数表法将其随机分为对照组（n=50）和研究组（n=51）。对照组给予常规西医治疗，研究组在对照组基础上联合化痰通络汤治疗，比较两组患者临床疗效，治疗前、治疗28d后的神经功能、血小板参数、血清炎性因子水平及治疗期间的不良反应发生情况。结果：两组患者治疗28d后美国国立卫生研究所卒中量表（NIHSS）评分均下降，且研究组低于对照组（P<0.05）。研究组的临床总有效率为88.24%（45/51），高于对照组的66.00%（33/50）（P<0.05）。两组治疗28d后血小板聚集率、血小板体积均下降，且研究组低于对照组（P<0.05）。两组治疗28d后血清白细胞介素-4（IL-4）、超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）水平均降低，且研究组低于对照组（P<0.05）。两组不良反应发生率对比无差异（P>0.05）。结论：采用化痰通络汤联合常规西医治疗缺血性卒中可有效改善患者血清炎性因子水平及血小板功能，减轻神经功能损伤，且用药安全性较好，具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effects of Huatan Tongluo decoction combined with conventional western medicine on neurological function, platelet function and serum inflammatory factors in patients with ischemic stroke. Methods: 101 patients with ischemic stroke who were admitted to our hospital from February 2016 to February 2019 were selected, they were randomly divided into control group (n=50) and study group (n=51) according to the digital table method. The control group was treated with routine western medicine, the study group was treated with Huatan Tongluo decoction on the basis of the control group. The clinical efficacy, neurological function, platelet parameters, serum inflammatory factors before treatment and 28 days after treatment and adverse reactions during treatment were compared between the two groups. Results: 28 days after treatment, the National Institutes of Health Stroke Scale (NIHSS) score of both groups decreased, and that of the study group was lower than that of the control group (P<0.05). The total clinical effective rate of the study group was 88.24% (45/51), which was higher than that of the control group 66.00% (33/50) (P<0.05). The platelet aggregation rate and platelet volume of both groups decreased at 28 days after treatment, and those of the study group were lower than those of the control group (P<0.05). The levels of serum interleukin-4 (IL-4), high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) of both groups decreased at 28 days after treatment, and those of the study group were lower than those of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The treatment of ischemic stroke with Huatan Tongluo decoction combined with routine western medicine can effectively improve the level of serum inflammatory factors and platelet function, alleviate neurological impairment, and it has good safety, which has certain clinical application value. |
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