| 付卫杰,郭元凯,陈 贺,赵志超,史凯旋,侯明轩,冯会成.原发性骨关节炎患者关节滑膜组织中NLRP3含量与炎症及氧化应激的相关性分析[J].,2020,(10):1992-1996 |
| 原发性骨关节炎患者关节滑膜组织中NLRP3含量与炎症及氧化应激的相关性分析 |
| Analysis of the Correlation between NLRP3 Content in the Joints and Inflammation and Oxidative Stress in Patients with Primary Osteoarthritis |
| 投稿时间：2019-12-28 修订日期：2020-01-24 |
| DOI：10.13241/j.cnki.pmb.2020.10.043 |
| 中文关键词: 原发性骨关节炎 核苷酸结合寡聚化结构域样受体3 凋亡相关斑点样蛋白 半胱氨酸天冬氨酸蛋白酶1 炎症 氧化应激 |
| 英文关键词: Primary osteoarthritis Nucleotide binding oligomerization domain like receptor 3 Apoptosis-associated spot-like proteins Cysteine aspartic proteinase 1 Inflammation Oxidative stress |
| 基金项目:国家自然科学基金项目（61871382）；保定市科学技术局科研项目（18ZF141） |
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| 中文摘要: |
| 摘要 目的：探讨原发性骨关节炎患者关节中核苷酸结合寡聚化结构域样受体3（NLRP3）含量与炎症及氧化应激的相关性。方法：选择2018年6月-2019年6月我院接诊的100例原发性骨关节炎患者进行研究，设为观察组，并选择我院同期体检健康者80例作为对照组。分析NLRP3、凋亡相关斑点样蛋白（ASC）、半胱氨酸天冬氨酸蛋白酶1（Caspase-1）与白介素1β（IL-1β）、白介素17（IL-17）、肿瘤坏死因子α（TNF-α）、丙二醛（MDA）、8-羟基脱氧鸟苷（8-OHdG）、3-硝基酪氨酸（3-NT）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）的相关性。结果：观察组NLRP3、ASC、Caspase-1水平显著高于对照组，差异显著（P<0.05）；观察组IL-1β、IL-17、TNF-α水平显著高于对照组，差异显著（P<0.05）；观察组MDA、8-OHdG、3-NT水平显著高于对照组，SOD、GSH-Px水平显著低于对照组，差异显著（P<0.05）；将炎症及氧化应激作为因变量，将NLRP3 、ASC、Caspase-1分别作为自变量，在相关性分析结果中显示，NLRP3、ASC、Caspase-1和IL-1β、IL-17、TNF-α、MDA、8-OHdG、3-NT之间均呈正相关（P＜0.05），NLRP3、ASC、Caspase-1和SOD、GSH-Px之间均呈负相关（P＜0.05）。结论：在原发性骨关节炎患者中NLRP3的含量和炎症及氧化应激之间存在着密切关系，可促使疾病进展。 |
| 英文摘要: |
| ABSTRACT Objective: To studyAnalysis of thecorrelation between Domain like receptor 3 (NLRP3) content in the joints and inflammation and oxidative stress in patients with primary osteoarthritis. Methods: 100 patients with primary osteoarthritis admitted to our hospital from June 2018 to June 2019 were selected as the observation group, and 80 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group. Analysis NLRP3, mottled protein (ASC) related to apoptosis, cysteine aspartic acid protease (Caspase 1) and interleukin 1 beta (IL-1 beta), interleukin 17 (IL-17), tumor necrosis factor alpha (TNF alpha), malondialdehyde (MDA), 8 - hydroxy deoxyguanosine (8-OHdG), 3-3-nitrotyrosine (3-NT) and superoxide dismutase (SOD), glutathione peroxidase (gsh-px) relevance. Results: The levels of NLRP3, ASC and caspase-1 in the observation group were significantly higher than those in the control group (P<0.05). Il-1 levels in the observation group were significantly higher than those in the control group (P<0.05). MDA, 8-ohdg and 3-nt levels in the observation group were significantly higher than those in the control group, while SOD and gsh-px levels were significantly lower than those in the control group (P<0.05). Inflammation and oxidative stress were taken as dependent variables, and NLRP3, ASC, and caspase-1 were taken as independent variables, respectively. Correlation analysis results showed that there was a positive correlation between NLRP3, ASC, caspase-1, il-1, il-17, TNF-, MDA, 8-ohdg, and 3-nt (P<0.05), and a negative correlation between NLRP3, ASC, caspase-1, SOD, and gsh-px (P<0.05). Conclusion: There is a close relationship between NLRP3 content and inflammation and oxidative stress in patients with primary osteoarthritis, which can promote disease progression. |
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