| 顾家琪,刘 剑,冯钟煦,李 丹,高建伟.微波治疗对痔瘘术后患者预后及血清NGF、PGE2、NPY水平的影响[J].,2020,(10):1966-1969 |
| 微波治疗对痔瘘术后患者预后及血清NGF、PGE2、NPY水平的影响 |
| Effect of Microwave Therapy on the Prognosis and Serum NGF, PGE2, NPY Levels of Patients after Hemorrhoidectomy |
| 投稿时间：2019-11-28 修订日期：2019-12-23 |
| DOI：10.13241/j.cnki.pmb.2020.10.037 |
| 中文关键词: 痔瘘切除术 微波治疗 炎症 神经生长因子 前列腺素E2 神经肽Y |
| 英文关键词: Hemorrhoid fistula resection Microwave treatment Inflammation Nerve growth factor Prostaglandin E2 And neuropeptide Y |
| 基金项目:秦皇岛市科学技术研究与发展计划项目（201602A241） |
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| 中文摘要: |
| 摘要 目的：探讨微波治疗对痔瘘术后患者的预后及血清神经生长因子（NGF）、前列腺素E2（PGE2）、神经肽Y（NPY）水平的影响。方法：选择我院2016年6月至2018年7月接诊的120例痔瘘术后患者，通过随机数表法分为对照组和观察组，每组60例。对照组给予常规治疗，观察组患者给予微波治疗。两组患者均连续治疗1周。比较两组治疗前后T淋巴细胞亚群、凝血功能、血清炎症因子、NGF、PGE2、NPY水平的变化情况、预后及并发症的发生情况。结果：治疗后，观察组CD3+、CD8+均高于对照组，CD4+/CD8+低于对照组（P＜0.05）；观察组凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）均长于对照组，纤维蛋白原（FIB）低于对照组（P＜0.05）；观察组血清CRP、TNF-α和PCT水平均明显优于对照组（P＜0.05），血清NGF、PGE2、NPY水平均低于对照组（P＜0.05）；观察组患者治疗后第3天和5天肛门水肿评分和创面愈合时间均少于对照组，创面愈合率高于对照组（P＜0.05）；观察组术后并发症的总发生率明显低于对照组（P＜0.05）。结论：微波治疗痔瘘术后患者能有效改善患者免疫功能，减轻炎症反应，降低血清NGF、PGE2、NPY水平，有利于促进患者恢复，且安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To study The effect of microwave therapy on the inflammation, prognosis and serum nerve growth factor (NGF), prostaglandin E2 (PGE2), and neuropeptide Y (NPY) levels of patients after hemorrhoidectomy. Methods: A total of 120 postoperative patients with hemorrhoidal fistula admitted in our hospital from June 2016 to July 2018 were selected and divided into a control group and an observation group by a random number table method, with 60 patients in each group. the control group was given conventional treatment, and the observation group was given microwave treatment. Patients in both groups were treated continuously for 1 week. The changes of T lymphocyte subsets, coagulation function, serum inflammatory factors, NGF, PGE2, NPY levels, prognosis and complications of the two groups were compared before and after treatment. Results: After treatment, the levels of serum CD3+ and CD8+ in the observation group were higher than those in the control group, and the levels of CD4+/CD8+ in the observation group were lower than those in the control group (P＜0.05); the prothrombin time (PT) and activated partial thromboplastin time (APTT) in the observation group were longer than those in the control group, while the fibrinogen (FIB) were lower than those in the control group (P＜0.05); the levels of CRP, TNF- α and PCT in the observation group were significantly higher than those in the control group (P＜0.05); the levels of serum NGF, PGE2 and NPY in the observation group were lower than those in the control group (P＜0.05); the score of anal edema and the time of wound healing in the observation group were lower than those in the control group on the 3rd and 5th day after treatment, and the wound healing rate was higher than that in the control group(P＜0.05); the total incidence of postoperative complications in the observation group was significantly lower than that in the control group(P＜0.05). Conclusion: Microwave treatment can effectively improve the immune function, reduce inflammatory response, serum NGF, PGE2, and NPY levels of patients with hemorrhoidal fistula. It can promote the recovery of patients with high safety. |
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