| 石永柱,吴大鹏,马 锋,李升平,陈 如.硝苯地平片联合酒石酸托特罗定片对TURP术后膀胱过度活动症的应用效果分析[J].,2020,(10):1913-1916 |
| 硝苯地平片联合酒石酸托特罗定片对TURP术后膀胱过度活动症的应用效果分析 |
| Analysis of the Effect of Nifedipine Tablets Combined with Tolterodine Tartrate Tablets on the Overactive Bladder Syndrome after TURP |
| 投稿时间：2019-12-04 修订日期：2019-12-27 |
| DOI：10.13241/j.cnki.pmb.2020.10.026 |
| 中文关键词: 经尿道前列腺电切术 膀胱过度活动症 硝苯地平片 酒石酸托特罗定片 临床疗效 安全性 |
| 英文关键词: Transurethral resection of the prostate Overactive bladder syndrome Nifedipine tablets Tolterodine Tartrate Tablets Clinical effect Safety |
| 基金项目:陕西省自然科学基金项目(2014JQ4008)；三二〇一医院院内计划项目(3201yk201508) |
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| 中文摘要: |
| 摘要 目的：探讨硝苯地平片联合酒石酸托特罗定片用于经尿道前列腺电切术(TURP)术后膀胱过度活动症的临床效果及安全性。方法：选择2015年8月至2017年8月我院接诊的103例TURP术后出现膀胱过度活动症的患者作为本研究对象，通过随机数表法将其分为试验组52例和对照组51例。两组均给予常规处理，对照组在此基础上口服酒石酸托特罗定片，2 mg/次，2次/d；试验组在对照组基础上联合硝苯地平片口服，5 mg/次，3次/d；两组均连续用药7d。比较两组临床疗效，治疗前后膀胱过度活动症(OABSS)评分、国际前列腺症(IPSS)评分、膀胱痉挛次数、排尿情况的变化以及不良反应的发生情况。结果：治疗后，试验组和对照组临床疗效总有效率分别为92.31%(48/52)和76.47%(39/51)，OABSS评分分别为(2.69±0.58)分和(4.76±0.62)分，IPSS评分分别为(5.02±0.80)分和(7.86±1.15)分，24h膀胱痉挛次数分别为(0.65±0.48)次和(1.10±0.61)次，24h尿急次数分别为(0.88±0.32)次和(1.59±0.54)次，24h排尿次数分别为(5.52±1.02)次和(7.24±0.97)次，夜间排尿次数分别为(0.73±0.45)次和(1.39±0.70)次，24 h平均尿量分别为(227.07±16.68)mL和(196.65±15.07)mL，试验组临床总有效率和24 h平均尿量均显著高于对照组(P＜0.05)，OABSS评分、IPSS评分、24 h膀胱痉挛次数、24 h尿急次数及24h排尿次数均显著低于对照组(P＜0.05)。两组不良反应发生率比较差异无统计学意义(P＞0.05)。结论：硝苯地平片联合酒石酸托特罗定片治疗TURP术后膀胱过度活动症患者的临床疗效明显优于单用酒石酸托特罗定片，其可更有效促进膀胱功能恢复，且不增加不良反应。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect and safety of nifedipine tablets combined with tolterodine tartrate tablets on the overactive bladder syndrome after transurethral resection of the prostate(TURP). Methods: 103 patients with overactive bladder syndrome after TURP who received therapy from August 2015 to August 2017 in our hospital were selected as research objects, according to random number table, those patients were divided into the 52 cases of treatment group and the 51 cases of control group. The were given routine treatment, on the basis of this, the control group was taken Tolterodine Tartrate Tablets orally, 2 mg/times, 2 times/d; on the basis of the control group, the treatment group was given nifedipine tablets orally, 5 mg/times, 3 times/d, the 2 groups was used continuously 7d. The clinical effects, the changes of Overactivity of bladder symptom score(OABSS) score, the International Prostatic Disease(IPSS) score, bladder spasm times and urination condition before and after the treatment, and the adverse reactions in the 2 groups were compared. Results: After treatment, the total effective rates of the treatment group and the control group were 92.31% (48/52) and 76.47% (39/51) respectively, the OABSS scores were(2.69±0.58) scores and (4.76±0.62) scores respectively, the IPSS scores were(5.02±0.80)scores and(7.86±1.15) scores respectively, the 24 h bladder spasm times were (0.65±0.48) times and (1.10±0.61) times respectively, the 24 h urgent urination times were(0.88±0.32) times and(1.59±0.54) times respectively, the 24 h urination times were(5.52±1.02) times and (7.24±0.97) times respectively, the nocturnal urination times were(0.73±0.45)times and(1.39±0.70) times respectively, 24 h mean urine volume were (227.07±16.68)mL and(196.65±15.07)mL respectively, the total clinical effective rate and 24h mean urine volume in the treatment group were significantly higher than that of the control group(P＜0.05), the OABSS scores, IPSS scores, 24 h bladder spasm times, 24 h urgent urination times and 24 h urination times were significantly lower than that of the control group(P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion: The clinical effect of Nifedipine tablets combined with tolterodine tartrate tablets on the overactive bladder syndrome after TURP is better than that of tolterodine tartrate tablets alone, which can effectively promote the recovery of bladder function, without increasing adverse reactions. |
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