| 费琳琳,陈 旺,许传智,高 伟,巨 丽.2型糖尿病患者心率变异性与心率减速力的相关性及其对自主神经功能的评估价值[J].,2020,(10):1901-1904 |
| 2型糖尿病患者心率变异性与心率减速力的相关性及其对自主神经功能的评估价值 |
| The Correlation between Heart Rate Variability and Heart Rate Deceleration in Type 2 Diabetes Mellitus and Its Evaluation Value on Autonomic Nervous Function |
| 投稿时间：2019-11-26 修订日期：2019-12-21 |
| DOI：10.13241/j.cnki.pmb.2020.10.023 |
| 中文关键词: 2型糖尿病 自主神经功能 心率变异性 心率减速力 相关性 评估 |
| 英文关键词: Type 2 diabetes mellitus Autonomic nervous function Heart rate variability Heart rate deceleration force Correlation study |
| 基金项目:安徽省科技攻关项目（1605a0812073） |
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| 中文摘要: |
| 摘要 目的：探讨2型糖尿病(T2DM)患者心率变异性(HRV)与心率减速力(DC)的相关性及其对自主神经功能的评估价值。方法：选取2018年1月~2019年12月期间合肥市第一人民医院收治的120例T2DM患者为研究对象，纳入实验组，其中单纯T2DM患者69例（单纯T2DM组），T2DM伴周围神经病变(DPN)患者51例（DPN组），另选同期在我院进行心功能检查的健康志愿者120例作为对照组。所有受试者均进行24h动态心电图检查，根据检查结果计算HRV值[总标准差(SDNN)、两个相邻RR间期互差(PNN50)、差值均方根(RMSSD)]和DC值，根据各组受试者的DC值，统计对比各组的猝死风险，并分析T2DM患者DC值与HRV各项指标的相关性。结果：对照组、单纯T2DM组、DPN组的SDNN、PNN50、RMSSD、DC值依次降低(均P<0.05)。对照组、单纯T2DM组、DPN组各猝死风险等级分布整体比较差异有统计学意义（P<0.05），单纯T2DM组、DPN组猝死高危比例显著高于对照组，且DPN组猝死高危比例高于单纯T2DM组(均P<0.05)。经Pearson相关分析，T2DM患者的DC值与SDNN、PNN50、RMSSD呈明显的正相关(P<0.05)。结论：T2DM患者的DC值、HRV指标均低于正常人群，合并DPN的T2DM患者猝死风险明显提高，DC值与HRV指标间存在明显的正相关，可作为T2DM患者自主神经功能状态评估的重要指标。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between heart rate variability (HRV) and heart rate decelerating force (DC) in patients with type 2 diabetes mellitus (T2DM) and its evaluation value for autonomic nervous function. Methods: 120 T2DM patients who were admitted to the first people's Hospital of Hefei city from June 2018 to December 2019 were selected as the study subjects and included in the experimental group, among them, 69 patients with T2DM alone (T2DM group), 51 patients with T2DM and DPN (DPN group), another 120 healthy volunteers were selected as the control group. According to the results of 24-hour Holter, the HRV values were calculated [total standard deviation (SDNN), Interval difference between two adjacent RRs (pNN50), Root mean square of difference（RMSSD）] and DC values, the risk of sudden death in each group was statistically compared according to the DC value of the subjects in each group, the correlation between DC and HRV was analyzed. Results: The values of SDNN, pNN50, RMSSD and DC in the control group, T2DM group and DPN group decreased in turn (P<0.05). There was significant difference in the risk distribution of sudden death among the control group, T2DM group and DPN group (P<0.05). The proportion of high-risk sudden death patients in T2DM group and DPN group was significantly higher than that in the control group, and the proportion of high-risk sudden death patients in DPN group was higher than that in T2DM group (P<0.05). the DC value of T2DM was positively correlated with SDNN, PNN50 and RMSSD through Pearson correlation analysis (P<0.05). Conclusion: The DC value and HRV index of patients with T2DM are lower than those of normal people, and the risk of sudden death of T2DM patients with DPN is significantly increased. There is a significant positive correlation between DC value and HRV index, which can be used as an important index to evaluate the autonomic nervous function of patients with T2DM. |
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