| 李小强,朱 辉,鲁翔宇,付 彤,李广泽.静息态功能磁共振在急性酒精中毒患者认知功能障碍评价分析[J].,2020,(10):1854-1857 |
| 静息态功能磁共振在急性酒精中毒患者认知功能障碍评价分析 |
| Evaluation of Cognitive Dysfunction in Patients with Acute Alcoholism by Resting State Functional Magnetic Resonance Imaging |
| 投稿时间：2019-11-25 修订日期：2019-12-21 |
| DOI：10.13241/j.cnki.pmb.2020.10.012 |
| 中文关键词: 静息态功能磁共振 急性酒精中毒 认知功能障碍 评价 |
| 英文关键词: Resting state functional magnetic resonance Acute alcoholism Cognitive dysfunction Evaluation |
| 基金项目:首都卫生发展科研专项基金项目(2016-1-2121） |
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| 中文摘要: |
| 摘要 目的：探讨静息态功能磁共振在急性酒精中毒患者认知功能障碍影响。方法：随机选取我院2018年4月-2019年4月收治治疗急性酒精中毒性脑病患者共60例，将患者作为研究组，另外选择健康实验成员30例作为对照组，对两组患者静息态功能磁共振检查结果及临床表现记录，有效观察和分析患者的认知功能障碍评分。结果：（1）研究组的模仿和回忆评分显著低于对照组（P<0.05）；（2）研究组的Rey-Osterrieth复杂图形测验（Complex figure test，CFT）测验结果异常比例为43.3 %（26/60），对照组为20.0 %（6/30），两组认知功能障碍差异对比有统计学意义（P<0.05）；（3）研究组简易智能量表测验（Mini-menta state examination, MMSE）、数字符号转换测试（Symbol Digit Modality Test，SDMT）和言语流畅性测验（Verbal fluency test，VFT）评分结果相比于对照组均显著降低（P<0.05）；（4）与对照组相比，研究组的左颞上回、右颞中回、右楔前叶、左后扣带回等脑区的功能连接均显著增强（P＜0.05）。结论：急性酒精患者由于乙醇代谢产物对人体的神经系统造成不利影响，因此对患者的认知功能障碍存在着不利影响，静息态功能磁共振对急性酒精中毒患者检测可以促使患者的认知功能障碍的变化情况更好显示出来，静息态功能磁共振对该病诊断价值较为显著。过量摄入酒精容易造成默认网络关键脑区损害问题突出，使得人体大脑基本功能受损。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the evaluation of cognitive dysfunction in patients with acute alcoholism by Resting-State fMRI. Methods: A total of 60 patients with acute alcoholic encephalopathy were enrolled in our hospital from April 2018 to April 2019. The patients were selected as the study group, and 30 healthy members were selected as the control group. The rest of the two groups were rested. The results of functional magnetic resonance imaging and clinical manifestations are effective in observing and summarizing the cognitive dysfunction scores of patients. Results: (1) The imitation and recall scores of the study group patients were significantly lower than those of the control group (P<0.05). (2) The abnormal proportion of CFT test results in the study group was 43.3 % (26/60), and that in the control group was 20.0 % (6/30), the difference in cognitive dysfunction between the two groups is statistically significant(P>0.05). (3) The MMSE, SDMT and VFT scores of the study group were significantly lower than those of the control group(P<0.05). (4) Compared with the control group, the functional connections of the left iliac crest, right iliac crest, right anterior cranial anterior lobes, and left posterior cingulate gyrus were significantly increased in the study group(P<0.05). Conclusion: Acute alcohol patients have adverse effects on the patient's cognitive dysfunction due to the adverse effects of ethanol metabolites on the human nervous system, and resting-state functional magnetic resonance (MRI) can induce patients with acute alcoholism. Changes in cognitive dysfunction are better shown, and resting-state functional magnetic resonance imaging has significant diagnostic value for the disease. The default network damage caused by excessive intake of alcohol is obvious, which causes the basic function of the human brain to be impaired. |
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