| 芦淑娟,张晓艳,关佳楠,孙 虓,张君杰.胃癌患者中CEA、AEP的表达及相关性分析[J].,2020,(9):1783-1787 |
| 胃癌患者中CEA、AEP的表达及相关性分析 |
| Expression and Correlation Analysis of CEA and AEP in Patients with Gastric Cancer |
| 投稿时间：2020-01-06 修订日期：2020-01-30 |
| DOI：10.13241/j.cnki.pmb.2020.09.040 |
| 中文关键词: 胃癌 T淋巴细胞亚群 凝血功能 癌胚抗原 天冬酰胺内肽酶 |
| 英文关键词: Gastric cancer T lymphocyte subsets Coagulation function Carcinoembryonic antigen Asparagine endopeptidase |
| 基金项目:辽宁省自然科学基金项目（2018102254） |
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| 中文摘要: |
| 摘要 目的：探讨胃癌患者中癌胚抗原（CEA）、天冬酰胺内肽酶（AEP）的表达及相关性分析。方法：回顾性分析2016年9月至2019年7月经手术切除102例胃癌组织蜡块标本的患者作为观察组，另随机抽取胃癌患者标本切缘的癌旁组织60例作为对照组。比较CEA、AEP在胃癌组组和癌旁组织的关系，且记录与临床病理参数之间的关系。结果：在胃癌组织中CEA、AEP的阳性表达率明显比癌旁组织高[47.06%（48/102）比3.33%（2/60），55.88%（57/102）比1.67%（1/60）]，差异有统计学意义（P＜0.05）；CEA、AEP和肿瘤大小、TNM分期、淋巴结转移、不同浸润程度、不同分化程度之间比较，差异有统计学意义（P＜0.05）；经Spearman相关性分析结果显示，胃癌组织中CEA、AEP和肿瘤大小、分化程度、TNM分期、淋巴结转移、浸润程度之间均呈正相关（P＜0.05）；经Pearson相关分析显示，在胃癌组织中CEA、AEP的表达均呈现正相关（r＝0.217，P＝0.010）。结论：CEA、AEP在胃癌患者组织中有明显高表达，和临床病理特征有明显相关性，且两者有相互协同效应，本研究也为胃癌预后判断、靶向治疗等提供了一定依据。 |
| 英文摘要: |
| ABSTRACT Objective: To study expression and correlation analysis of carcinoembryonic antigen (CEA) and asparagine endopeptidase (AEP) in gastric cancer patients. Methods: A retrospective analysis was made on 102 patients with gastric cancer tissue wax samples surgically removed from September 2016 to July 2019 as the observation group, and 60 adjacent tissues in the margin of gastric cancer were randomly selected as the control group. The relationship between CEA, AEP and clinicopathological parameters was compared in gastric cancer group and adjacent tissues. Results: The positive expression rate of CEA and AEP in gastric cancer was significantly higher than that in adjacent tissues[47.06%（48/102）vs 3.33%（2/60）, 55.88%（57/102）vs 1.67%（1/60）], the difference has statistically significant（P＜0.05）; CEA, AEP and tumor size, TNM stage, lymph node metastasis, different degree of infiltration, the difference has statistically significant（P＜0.05）; the Spearman correlation analysis showed that there was a positive correlation between CEA, AEP and tumor size, degree of differentiation, TNM stage, lymph node metastasis, and degree of invasion in gastric cancer tissues（P＜0.05）; the Pearson correlation analysis showed that CEA and AEP were positively correlated in gastric cancer(r= 0.217, P = 0.010). Conclusion: The CEA and AEP are highly expressed in gastric cancer tissues, which have obvious correlation with clinicopathological features, and they have synergistic effect. This study also provides a certain basis for prognosis judgment and targeted treatment of gastric cancer. |
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