| 贺 娟,肖伟利,任志宏,丁海涛,云宇婷.血清AFP、CEA与肝癌患者临床病理分期和预后的关系及其诊断价值分析[J].,2020,(8):1501-1505 |
| 血清AFP、CEA与肝癌患者临床病理分期和预后的关系及其诊断价值分析 |
| The Relationship between Serum AFP, CEA and Clinicopathological Staging and Prognosis in Patients with Hepatocellular Carcinoma and Its Diagnostic Value |
| 投稿时间：2019-11-06 修订日期：2019-11-30 |
| DOI：10.13241/j.cnki.pmb.2020.08.022 |
| 中文关键词: 甲胎蛋白 癌胚抗原 肝癌 TNM分期 预后 |
| 英文关键词: Alpha-fetoprotein Carcinoembryonic antigen Hepatocellular carcinoma TNM stage Prognosis |
| 基金项目:内蒙古自治区科技计划项目（201602097） |
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| 中文摘要: |
| 摘要 目的：探讨血清甲胎蛋白（AFP）、癌胚抗原（CEA）与肝癌患者临床病理分期和预后的关系及其诊断价值。方法：选取2010年3月至2014年4月期间我院就诊的90例肝癌患者作为肝癌组，并选择同期在我院进行体检的90例健康体检者作为健康组。统计两组的血清AFP、CEA水平及阳性率，比较不同TNM分期肝癌患者的血清AFP和CEA水平。分析肝癌患者的5年无复发生存率以及血清AFP和CEA水平对肝癌的诊断价值。结果：与健康组相比，肝癌组血清AFP、CEA水平及阳性率明显升高（P<0.05）。Ⅳ期血清AFP和CEA水平最高，其次Ⅲ期，Ⅱ期次之，Ⅰ期最低（P<0.05）。血清AFP、CEA阳性患者5年无复发生存率明显低于血清AFP、CEA阴性患者（P<0.05），血清AFP、CEA联合诊断具有较高的敏感性和特异性。结论：肝癌患者的血清AFP和CEA水平升高，并随TNM分期增加而上调。血清AFP阳性以及CEA阳性患者的5年无复发生存率明显下降，血清AFP联合血清CEA检测在肝癌诊断中具有一定的临床价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between serum alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and clinicopathological staging and prognosis in patients with hepatocellular carcinoma and its diagnostic value. Methods: From March 2010 to April 2014, 90 patients with hepatocellular carcinoma who were treated in our hospital were selected as the liver cancer group. 90 healthy patients who underwent physical examination in our hospital during the same period were selected as the healthy group. The serum AFP, CEA levels and positive rates of the two groups were analyzed, and serum AFP and CEA levels of patients with different stages of liver cancer were compared. The 5-year recurrence-free survival rate in patients with hepatocellular carcinoma and the diagnostic value of serum AFP and CEA levels were analyzed. Results: Compared with the healthy group, serum AFP, CEA levels and positive rates in liver cancer group were significantly increased (P<0.05). On the serum AFP and CEA levels, the patients of Ⅳ period were the highest, secondly patients of Ⅲ period, next the patients of Ⅱ period, patients of Ⅰ period were the lowest (P<0.05). The 5-year recurrence-free survival rate of serum AFP and CEA positive patients were significantly lower than those of serum AFP and CEA negative patients (P<0.05), and the combined diagnosis of serum AFP and CEA had higher sensitivity and specificity. Conclusion: Serum AFP and CEA levels in patients with hepatocellular carcinoma are increased, and upregulated with TNM stages. The 5-year recurrence-free survival rate of serum AFP and CEA positive patients are significantly decreased. Serum AFP combined with serum CEA has a certain clinical value in the diagnosis of liver cancer. |
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