| 程文广,邓大京,褚志刚,叶子青,王建华.壳聚糖护创敷料用于烧伤创面的治疗效果和安全性研究[J].,2020,(7):1389-1392 |
| 壳聚糖护创敷料用于烧伤创面的治疗效果和安全性研究 |
| Therapeutic Effect and Safety of Chitosan Wound Dressing for Burn Wounds |
| 投稿时间：2019-11-23 修订日期：2019-12-18 |
| DOI：10.13241/j.cnki.pmb.2020.07.042 |
| 中文关键词: 烧伤创面 壳聚糖护创敷料 愈合 临床效果 |
| 英文关键词: Burn wound Chitosan wound dressing Healing Clinical effect |
| 基金项目:湖北省自然科学基金面上项目（2016CFB589） |
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| 中文摘要: |
| 摘要 目的：探讨壳聚糖护创敷料用于烧伤创面的治疗效果和安全性。方法：采用回顾性方法分析，选取中国人民解放军空降兵军医院烧伤科（本院）自2014年1月-2018年9月就诊的80例烧伤患者的临床资料，根据治疗方法分为对照组（40例，给予单纯紫草油覆盖创面）与研究组（40例，给予壳聚糖护创敷料覆盖创面），比较两组创面愈合时间、疼痛度、瘢痕生长及不同时期分泌物细菌培养阳性率。结果：研究组的创面愈合时间（18.45±4.64）及瘢痕生长评分（3.23±1.12）均低于对照组（22.45±5.23、5.34±1.23），均有显著差异（P<0.05）。治疗后7 d、14 d、21 d研究组的创面疼痛度低于对照组（P<0.05）。治疗后3 d、7 d、14 d研究组的细菌培养阳性率低于对照组（P<0.05）。两组治疗期间均没有出现不良事件和严重不良事件的发生。结论：壳聚糖护创敷料用于烧伤创面患者治疗中，可缩短创面愈合时间，抑菌，减少创面愈合后的瘢痕增生，从而减轻患者疼痛，安全性高，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy and safety of chitosan wound dressing in treating burn wounds. Methods: The clinical data of 80 burn patients treated in our hospital from January 2014 to September 2018 were retrospectively analyzed. According to the treatment methods, the patients were divided into the control group (40 cases were treated with purely shikonin oil) and the research group (40 cases were treated with chitosan wound dressing). The wound healing time, pain degree, scar growth and positive rate of bacterial culture in different periods were compared between the two groups. Results: The wound healing time (18.45±4.64) and scar growth score (3.23±1.12) in the study group were lower than those in the control group (22.45±5.23, 5.34±1.23), and there were significant differences(P<0.05). The wound pain of the study group was significantly lower than that of the control group at 7 d, 14 d, and 21 d after treatment(P<0.05). The positive rate of bacterial culture in the study group was lower than that in the control group at 3 d, 7 d, and 14 d after treatment(P<0.05). No adverse events and serious adverse events occurred during the treatment period. Conclusion: The chitosan wound dressing is used in the treatment of patients with burn wounds, which can shorten the wound healing time, inhibit bacteria and reduce the scar hyperplasia after wound healing. Hence, it can reduce the pain of patients with high safety characteristics and is worthy of clinical application. |
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