| 马丽亚,任卫星,马 华,马 萌,张忠广.新生儿接种两种剂型乙型肝炎疫苗不同时间的免疫水平比较[J].,2020,(7):1317-1321 |
| 新生儿接种两种剂型乙型肝炎疫苗不同时间的免疫水平比较 |
| Comparison of Immunization Levels of Neonates Treated by Two Doses of Hepatitis B Vaccine at Different Times |
| 投稿时间：2019-07-17 修订日期：2019-08-12 |
| DOI：10.13241/j.cnki.pmb.2020.07.025 |
| 中文关键词: 乙肝疫苗 乙肝疫苗 免疫水平 |
| 英文关键词: Hepatitis B vaccine Hepatitis B vaccine Immune level |
| 基金项目:山东省自然科学基金项目(SX20180367F)；青岛市扬帆计划项目(QY2018034Z) |
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| 中文摘要: |
| 摘要 目的：研究接种两种不同剂型的乙肝疫苗(Hepatitis B vaccine，HepB)(包括10 μg CHO基因工程乙肝疫苗(以下简称10 μg HepB)与5 μg重组酵母乙肝疫苗(以下简称5 μg HepB))后不同时间，新生儿体内免疫水平的变化，为新生儿乙肝疫苗的接种提供科学依据。方法：选择2016年7月1日-2018年12月1日在青岛大学附属医院接种且按照0、1、6个月免疫程序完成乙型肝炎疫苗全程接种的，采用化学放光法测定血清中抗体水平，比较接种10 μg与5 μg HepB后不同时间新生儿体内抗体变化。结果：接种1、6和12月后，10 μg HepB组新生儿低无应答率显著低于5 μg HepB组，而肝表面抗体滴度明显高于5 μg HepB组(P<0.05)；12个月后，两组新生儿乙肝表面抗体滴度均呈现下降趋势；10 μg HepB组新生儿乙肝表面抗体阳性率仍显著高于5 μg HepB组(P<0.05)。结论：新生儿接种10 μg HepB的免疫效果优于5 μg HepB。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the changes in the level of immunity in neonates treated by two different dosage types of Hepatitis B vaccine (HepB) (including 10 μg CHO genetically engineered hepatitis B vaccine (hereinafter referred to as 10 μg HepB) and 5 μg recombinant yeast hepatitis B vaccine (hereinafter referred to as 5 μg HepB)) for different time, and, provide a scientific basis for the vaccination of neonatal hepatitis B vaccine. Methods: The vaccination of the hepatitis B vaccine in accordance with the 0, 1, and 6-month immunization procedures from July 1, 2016 to December 1, 2016 were selected, and the serum antibody levels were measured by chemical concentrating method, the changes of antibody in the neonates after inoculation with 10 μg and 5 μg of HepB at different time points were compared. Results: After 1, 6 and 12 months of inoculation, the low non-response rate of neonates in the 10 μg HepB group was significantly lower than that in the 5 μg HepB group, while the antibody titer on the liver surface was significantly higher than that in the 5 μg HepB group (P<0.05); at 12 months after inoculation, the antibody titer of hepatitis B in both groups showed a downward trend; the positive rate of hepatitis B surface antibody in newborns of 10 μg HepB group was significantly higher than that in 5 μg HepB group (P<0.05). Conclusion: Neonatal inoculation with 10 μg HepB is superior to 5 μg HepB. |
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