| 郭绍文,吴雪卿,冯佳梅,任玉倩,吴丽莉,冯 真,宋晓艳,万 华.雌激素和孕激素受体在粉刺性乳痈的表达及意义[J].,2020,(7):1281-1284 |
| 雌激素和孕激素受体在粉刺性乳痈的表达及意义 |
| A Study on the Expression and Clinical Significance of Estrogen and Progesterone Receptor in the Acne Breast Carbuncle |
| 投稿时间：2019-07-28 修订日期：2019-08-23 |
| DOI：10.13241/j.cnki.pmb.2020.07.016 |
| 中文关键词: 粉刺性乳痈 雌激素受体 孕激素受体 炎性因子 |
| 英文关键词: Acneous mammary carbuncle Estrogen receptors Progesterone receptor Inflammatory factors |
| 基金项目:上海市科学技术委员会科研计划项目(19401934000) |
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| 中文摘要: |
| 摘要 目的：探讨粉刺性乳痈患者雌激素受体(ER)、孕激素受体(PR)的表达及临床意义。方法：选择我院2017年1月~2018年12月收治的80例粉刺性乳痈患者，采用免疫组化法检测其乳腺病变组织ER、PR的表达，酶联免疫吸附法(ELISA)检测血清白介素-1β(interleukin-1β, IL-1β)、IL-6及肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)水平，分析乳腺病变组织ER、PR的表达与血清IL-1β、IL-6、TNF-α水平的相关性。结果：与普通乳腺炎组、乳腺导管扩张组比较，肉芽肿组、脓肿组血清IL-1β、IL-6、TNF-α水平明显升高，与肉芽肿组比较，脓肿组血清IL-1β、IL-6、TNF-α水平亦明显升高(P<0.05)。普通乳腺炎组、乳腺导管扩张组血清IL-1β、IL-6、TNF-α水平比较差异无统计学意义(P>0.05)。普通乳腺炎组、乳腺导管扩张组、肉芽肿组、脓肿组ER、PR的表达水平依次降低(P<0.05)。普通乳腺炎组、乳腺导管扩张组ER、PR的表达与血清IL-1β、IL-6水平均呈显著负相关，而与血清TNF-α水平无显著相关性(P>0.05)；肉芽肿组、脓肿组ER、PR表达与血清IL-1β、IL-6、TNF-α水平均呈显著负相关(P<0.05)。结论：粉刺性乳痈患者ER、PR呈低表达或失表达，且与炎症因子及病情严重程度具有良好相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of of estrogen receptor (ER) and progesterone receptor (PR) in patients with acne breast carbuncle, and analyze their correlation with inflammatory factors. Methods: The expression of ER and PR in the breast lesions was detected by immunohistochemistry in 80 cases of acne breast carbuncle admitted to our hospital from January 2017 to December 2018, and serum levels of IL-1β, IL-6 and TNF-α were detected by enzyme-linked immunosorption (ELISA) to analyze the correlation between the expression of ER and PR in the breast lesions and serum levels of IL-1β, IL-6 and TNF-α levels. Results: Compared with mastitis group and mammary dilatation group, the serum levels of IL-1β, IL-6 and TNF-α in the granuloma group and abscess group were significantly increased, and compared with the granuloma group, the serum levels of IL-1β, IL-6 and TNF-α in abscess group were also significantly increased (P<0.05). There was no significant difference in the serum levels of IL-1β, IL-6 and TNF-α between mastitis group and mammary expansion group (P>0.05). The expression levels of ER and PR in the mastitis group, mammary dilatation group, granuloma group and abscess group were successively reduced(P<0.05). The expression of ER and PR were negatively correlated with serum levels of IL-1β, IL-6, but showed no significant correlation with the serum TNF-α level in the mastitis group and the mammary dilatation group(P>0.05). The ER and PR expression in granuloma group and abscess group were significantly negatively correlated with the serum levels of IL-1β, IL-6, TNF-α(P<0.05). Conclusion: Acne breast carbuncle has low or loss expression of ER and PR, which were significantly correlated with the inflammatory factors and severity of disease. |
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