文章摘要
向 玉,权祥菊,杨惠林,马英兰,武学海,武薇薇.定坤丹对多囊卵巢综合征患者性激素水平、胰岛素抵抗及妊娠情况的影响[J].,2020,(3):578-581
定坤丹对多囊卵巢综合征患者性激素水平、胰岛素抵抗及妊娠情况的影响
Effects of Dinkundan on the Sex Hormone Levels, Insulin Resistance and Pregnancy in Patients with PCOS
投稿时间:2019-07-03  修订日期:2019-07-27
DOI:10.13241/j.cnki.pmb.2020.03.039
中文关键词: 定坤丹  多囊卵巢综合征  性激素  胰岛素抵抗  妊娠率
英文关键词: Dingkundan  Polycystic ovary syndrome  Sex hormone levels  Insulin resistance  The pregnancy rate
基金项目:青海省科学技术厅基金项目(2016-ZJ-797)
作者单位E-mail
向 玉 青海红十字医院生殖中心 青海 西宁 810000 zhangweidong198209@163.com 
权祥菊 青海大学附属医院产科 青海 西宁 810001  
杨惠林 青海红十字医院生殖中心 青海 西宁 810000  
马英兰 青海红十字医院生殖中心 青海 西宁 810000  
武学海 青海红十字医院生殖中心 青海 西宁 810000  
武薇薇 青海红十字医院生殖中心 青海 西宁 810000  
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中文摘要:
      摘要 目的:探讨定坤丹对多囊卵巢综合征患者性激素水平、胰岛素抵抗及妊娠情况的的影响。方法:选择2016年5月至2018年5月我院收治的210例多囊卵巢综合征患者,根据随机化原则将其分为两组,每组105例。对照组患者接受达英-35与二甲双胍治疗,研究组在对照组的基础上口服定坤丹治疗。连续治疗3个月后,比较两组治疗前后的性激素水平及胰岛各相关指标的变化。治疗结束后随访1年,比较两组的排卵及妊娠情况。结果:与治疗前相比,两组治疗后的血清睾酮(Testosterone,T)、黄体生成素(Luteinizing hormone,LH)及LH/FSH均明显降低,且研究组以上指标均显著低于对照组(P<0.05)。两组治疗前后的卵泡刺激素(Follicle-stimulating hormone,FSH)水平比较无统计学差异(P>0.05)。与治疗前相比,两组治疗后的空腹胰岛素(Fasting insulin,FINS)、餐后2 h胰岛素(Postprandial 2 hours insulin,2hPINS)及β细胞胰岛素分泌功能(Homeostasis model assessment of β cell,HOMA-β)均明显升高,胰岛素敏感指数(Homeostasis model assessment-Insulin sensitivity index,HOMA-IS)明显降低,且研究组以上指标较对照组改善更明显(P<0.05)。研究组排卵及成功妊娠率均显著高于对照组(P<0.05)。结论:定坤丹有助于改善多囊卵巢综合征患者性激素水平及胰岛素抵抗,提高排卵及妊娠率。
英文摘要:
      ABSTRACT Objective: To investigate the effect of dinkundan on sex hormone level, insulin resistance and pregnancy in patients with PCOS. Methods: 210 patients with PCOS were selected as objects from May 2016 to May 2018. According to the admission single and double number, 105 patients in the control group received Da-35 and metformin therapy, and 105 patients in the study group received were treated with dinkundan orally on the basis of the control group. After continuous treatment for 3 months, the changes of sex hormone levels and islet related indicators before and after treatment in the two groups were compared,The ovulation and pregnancy of the two groups were compared after 1 year follow-up. Results: Compared with before treatment, T, LH/FSH and LH of the two groups were significantly reduced after treatment, and the experimental group was significantly lower than the control group(P<0.05). There was no statistically significant difference in FSH level between the two groups before and after treatment(P>0.05). Compared with before treatment, FINS, 2hPINS and homa-beta of the two groups were significantly increased after treatment, while homa-is was significantly decreased. Moreover, the improvement of the research group was more significant than that of the control group(P<0.05). The ovulation and successful pregnancy rates in the study group were significantly higher than those in the control group(P<0.05). Conclusion: Dinkundan helps improve sex hormone levels and patients' insulin resistance, increased ovulation and pregnancy rates, It has high application value in the treatment of PCOS.
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