文章摘要
王妮妮,刘 娜,王汝菲,杨光磊,李新东.55岁以下急性冠状动脉综合征的影响因素分析[J].,2020,(3):565-568
55岁以下急性冠状动脉综合征的影响因素分析
Analysis of Influencing Factors in Patients with Acute Coronary Syndrome under 55 Years Old
投稿时间:2019-07-03  修订日期:2019-07-27
DOI:10.13241/j.cnki.pmb.2020.03.036
中文关键词: 急性冠状动脉综合征  预后  性别差异
英文关键词: Acute coronary syndrome (ACS)  Prognosis  Sex differences
基金项目:国家卫生计生委医药卫生科技发展研究项目(w2015CAE173)
作者单位E-mail
王妮妮 锦州医科大学附属第四临床学院心血管内科(盘锦辽油宝石花医院) 辽宁 盘锦 124010 wangnini11011@163.com 
刘 娜 锦州医科大学附属第四临床学院病案室(盘锦辽油宝石花医院) 辽宁 盘锦 124010  
王汝菲 锦州医科大学附属第四临床学院心血管内科(盘锦辽油宝石花医院) 辽宁 盘锦 124010  
杨光磊 锦州医科大学附属第四临床学院心血管内科(盘锦辽油宝石花医院) 辽宁 盘锦 124010  
李新东 锦州医科大学附属第四临床学院心血管内科(盘锦辽油宝石花医院) 辽宁 盘锦 124010  
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中文摘要:
      摘要 目的:探究55岁以下急性冠状动脉综合征(Acute coronary syndrome,ACS)患者的影响因素。方法:选择2010年3月至2013年3月于我院就诊的180例55岁以下ACS患者为研究对象,按照其性别将其区分为男性组(101例)和女性组(79例)。收集和比较两组患者一般临床资料,血清血红蛋白(Hemoglobin,HGB)、甘油三酯(Triglyceride,TG)、胆固醇(Cholesterol,TC)、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(High density lipoprotein cholesterol,HDL-C)、血尿酸水平。对两组患者进行5年随访,对比两组患者心血管不良事件(Major adverse cardiovas-cular events,MACE)的发生率、死亡率及再发病率。结果:(1)女性组平均发病年龄高于男性组,女性组伴发高血压、糖尿病、脑卒中比率高于男性组,男性组吸烟史比率高于女性组(P<0.05),两组BMI、心血管病家族史对比差异无统计学意义(P>0.05);(2)女性组TC、TG、LDL-C、HDL-C水平均高于男性组(P<0.05),女性组血尿酸水平低于男性组(P<0.05);(3)对比5年预后,男性组MACE发生率为9.90 %(10/101),女性组MACE发生率为11.39 %(9/79),男性组死亡率为1.98 %(2/101),女性组为1.27 %(1/79),再发病率男性组为5.94 %(6/101),女性组为6.33 %(5/79),两组上述指标对比差异均无统计学意义(P>0.05)。结论:女性ACS患者发病年龄高于男性患者,糖尿病、高血压等病对女性患者影响更为明显,而吸烟则对男性影响更大,女性ACS患者血脂、血尿酸等指标异常程度甚于男性患者,但女性与男性患者远期预后相当。
英文摘要:
      ABSTRACT Objective: To investigate the influencing factors of patients with acute coronary syndrome (ACS) of different genders under 55 years old. Methods: 180 ACS patients under 55 years old who were admitted to our hospital from March 2010 to March 2013 were selected as the research objects. They were divided into the male group (101 cases) and the female group (79 cases) according to their gender. The general clinical data of the two groups were collected and compared, serum HGB, TG, TC, LDL-C, HDL-C, and blood uric acid levels. The two groups of patients were followed up for 5 years. The incidence, mortality and recurrence rate of major adverse cardiovas-cular events (MACE) were compared between the two groups. Results: (1) The average age of onset in the female group was higher than that in the male group, the rate of hypertension, diabetes and stroke in the female group was higher than that in the male group, and the rate of smoking history in the male group was higher than that inthe female group(P<0.05). There was no significant difference between the two groups in BMI and family history of cardiovascular diseases(P>0.05). (2) The levels of TC, TG, LDL-C and HDL-C in female group were higher than those in male group(P<0.05), and the blood uric acid level in female group was lower than that in male group(P<0.05). (3) Compared with the 5-year prognosis, the incidence of MACE in the male group was 9.90 % (10/101), that in the female group was 11.39 % (9/79), that in the male group was 1.98 % (2/101), and that in the female group was 1.27 % (1/79). The recurrence rate was 5.94 % (6/101) in the males group and 6.33 % (5/79) in the females group. There was no significant difference between the two groups(P>0.05). Conclusion: The age of onset of female ACS patients is higher than that of male patients. Diabetes, hypertension and other diseases have more obvious effects on female patients, while smoking has a greater impact on men. Female ACS patients have abnormalities in blood lipids, blood uric acid and other indicators than male patients. Female and male patients have a long-term prognosis.
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