文章摘要
赵凤春,李淑萍,张 芃,赵 婕,王胜来.血小板输注无效与血小板抗原(HPA)多态性的相关性[J].,2020,(3):493-496
血小板输注无效与血小板抗原(HPA)多态性的相关性
Correlation between Platelet Transfusion Refractoriness and Platelet Antigen (HPA) Polymorphism
投稿时间:2019-08-06  修订日期:2019-08-29
DOI:10.13241/j.cnki.pmb.2020.03.019
中文关键词: 血小板输注无效  人类血小板抗原  基因多态性  相关性
英文关键词: Platelet transfusion refractoriness  Human platelet antigen  Gene polymorphism  Correlation
基金项目:国家自然科学基金项目(81371861)
作者单位E-mail
赵凤春 首都医科大学附属北京同仁医院输血科 北京 100730 zfc20190731@163.com 
李淑萍 首都医科大学附属北京同仁医院输血科 北京 100730  
张 芃 北京医院输血科 北京 100005  
赵 婕 首都医科大学附属北京友谊医院ICU 北京 100050  
王胜来 首都医科大学附属北京同仁医院检验科 北京 100730  
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中文摘要:
      摘要 目的:探讨血小板输注无效(PTR)与血小板抗原(HPA)多态性的相关性。方法:2017年5月到2018年9月选择在首都医科大学附属北京同仁医院输血科进行血小板输注的患者187例,检测所有患者血液的HPA多态性,判断PTR发生情况并进行相关性分析。结果:在187例患者中,发生PTR 32例,发生率为17.1 %。PTR患者的HPA1、HPA2、HPA3、HPA4、HPA5的b基因频率都显著高于非PTR患者(P<0.05),也都呈基因多态性分布;非PTR患者都呈aa纯合子单性态分布。在187例患者中,直线相关分析显示HPA1、HPA5基因多态性与PTR有显著相关性(P<0.05),与HPA2、HPA3、HPA4基因多态性无相关性(P>0.05)。Logistic回归分析显示HPA1基因多态性、HPA5基因多态性、再生障碍性贫血、骨髓增生异常综合症为导致PTR的影响因素(P<0.05)。结论:血小板输注中PTR比较常见,多伴随有HPA多态性,HPA1 和HPA5基因多态性、再生障碍性贫血、骨髓增生异常综合症为导致PTR的影响因素。
英文摘要:
      ABSTRACT Objective: To investigate the association between platelet transfusion refractoriness(PTR)and platelet antigen (HPA) polymorphism. Methods: From May 2017 to September 2018, 187 patients who underwent platelet transfusion in Department of Blood Transfusion, Beijing Tongren Hospital, Capital Medical University were selected. The HPA polymorphism in all patients were measured, and the incidence of PTR were determined and were given correlation analysis. Results: In 187 patients, 32 patients of PTR occurred, the incidence rates was 17.1 %. The b gene frequencies of HPA1, HPA2, HPA3, HPA4, and HPA5 in PTR patients were significantly higher than those in non-PTR patients (P<0.05), and all of them were genetic polymorphism distribution; non-PTR patients were all aa homozygous single-sex distribution. In the 187 patients, linear correlation analysis showed that HPA1 and HPA5 gene polymorphisms were significantly associated with PTR(P<0.05), and no correlated with HPA2, HPA3, HPA4 gene polymorphisms (P>0.05). Logistic regression analysis showed that HPA1 gene polymorphism, HPA5 gene polymorphism, aplastic anemia, and myelodysplastic syndrome were the influencing factors of PTR(P<0.05). Conclusion: PTR are common in platelet transfusion, and are associated with HPA polymorphism. HPA1 and HPA5 polymorphism, aplastic anemia, and myelodysplastic syndrome are the influencing factors of PTR.
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