文章摘要
王 庆,田海涛,王鸿燕,李 晶,牛绍莉,许如意.血清同型半胱氨酸及超敏C反应蛋白水平与老年原发性高血压患者颈动脉粥样硬化程度的关系研究[J].,2020,(3):484-487
血清同型半胱氨酸及超敏C反应蛋白水平与老年原发性高血压患者颈动脉粥样硬化程度的关系研究
Relationship between the Levels of Serum Homocysteine and Hypersensitive C-reactive Protein Levels and Carotid Atherosclerosis in Elderly Patients with Essential Hypertension
投稿时间:2019-07-07  修订日期:2019-07-30
DOI:10.13241/j.cnki.pmb.2020.03.017
中文关键词: 同型半胱氨酸  超敏C反应蛋白  原发性高血压  颈动脉粥样硬化  危险因素
英文关键词: Homocysteine  Hypersensitive C-reactive protein  Essential hypertension  Carotid atherosclerosis  Risk factors
基金项目:北京市科技计划科研项目(Z161100000516186)
作者单位E-mail
王 庆 中国人民解放军总医院第六医学中心干部心血管内科 北京 100048 wangqiqiqi81@163.com 
田海涛 中国人民解放军总医院第六医学中心干部心血管内科 北京 100048  
王鸿燕 中国人民解放军总医院第六医学中心干部心血管内科 北京 100048  
李 晶 中国人民解放军总医院第六医学中心干部心血管内科 北京 100048  
牛绍莉 中国人民解放军总医院第六医学中心干部心血管内科 北京 100048  
许如意 中国人民解放军总医院第六医学中心干部心血管内科 北京 100048  
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中文摘要:
      摘要 目的:探讨血清同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)水平与老年原发性高血压患者颈动脉粥样硬化程度的关系。方法:选择我院于2015年5月至2017年10月收治的141例老年原发性高血压患者作为研究对象。检测所有患者颈动脉内膜-中层厚度(IMT),并根据IMT将其分为正常组(IMT≤1.0 mm,n=28)、增厚组(1.0 mm<IMT<1.5 mm,n=53)和斑块组(IMT≥1.5 mm,n=60)。比较三组患者血清Hcy、hs-CRP、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平,采用Pearson相关分析四项指标与IMT的相关性,采用多元线性逐步回归分析IMT增厚的影响因素。结果:增厚组与斑块组血清Hcy、hs-CRP、TC、LDL-C水平均明显高于正常组,且斑块组血清Hcy、hs-CRP、TC、LDL-C水平明显高于增厚组,差异具有统计学意义(均P<0.05)。Pearson相关分析结果表明,血清Hcy、hs-CRP、TC、LDL-C水平均与IMT呈正相关关系(r=0.775、0.836、0.492、0.415,均P<0.05)。多元线性逐步回归分析结果显示,血清Hcy、hs-CRP均为IMT增厚的独立危险因素(OR=5.689、7.381,均P<0.05)。结论:老年原发性高血压患者颈动脉粥样硬化程度与血清Hcy、hs-CRP关系密切,临床上检测其Hcy、hs-CRP水平可在一定程度上评估颈动脉粥样硬化程度。
英文摘要:
      ABSTRACT Objective: To investgate the relationship between the levels of serum homocysteine (Hcy) and hypersensitive C-reactive protein (hs-CRP) and carotid atherosclerosis in elderly patients with essential hypertension. Methods: 141 elderly patients with essential hypertension admitted to our hospital from May 2015 to October 2017 were selected as the subjects of study. Carotid intima-media thickness (IMT) was measured in all patients, who were divided into normal group (IMT≤1.0 mm, n=28), thickening group (1.0 mm<IMT<1.5 mm, n=53) and plaque group (IMT≥1.5 mm, n=60) according to IMT. The levels of serum Hcy, hs-CRP, total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) were compared among the three groups, Pearson correlation analysis was used to analyze the correlation between four indicators and IMT, While multivariate linear stepwise regression analysis was used to analyze the influencing factors of IMT thickening. Results: The levels of serum Hcy, hs-CRP, TC and LDL-C in the thickening group and the plaque group were significantly higher than those in the normal group, and the levels of serum Hcy, hs-CRP, TC and LDL-C in the plaque group were significantly higher than those in the thickening group, the difference has statistical significance (All P<0.05). Pearson correlation analysis showed that serum Hcy, hs-CRP, TC, LDL-C levels were positively correlated with IMT (r=0.775, 0.836, 0.492, 0.415, all P<0.05). Multiple linear stepwise regression analysis showed that serum Hcy and hs-CRP were independent risk factors for IMT thickening (OR=5.689, 7.381, all P<0.05). Conclusion: The degree of carotid atherosclerosis in elderly patients with essential hypertension is closely related to serum Hcy and hs-CRP. Clinical detection of their Hcy and hs-CRP levels can assess the degree of carotid atherosclerosis to a certain extent.
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